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Flashcards in Oncogenes Deck (19)
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1

What are the growth factor receptors?

1. ERB-2 (her2/neu)
2. Ret
3. Kit

2

What are the signal transducers?

1. Ras
2. ABL

3

What are the nuclear regulators?

1. C-myc
2. N-myc
3. L-myc

4

What are the cell cycle regulators?

1. Cyclin D1
2. CDK4

5

What are the tumor suppressor genes?

1. p53
2. Rb

6

What is the regulator of apoptosis?

Bcl2

7

What is the f=growth factor?

PDGF

8

PDGF

- overexpression seen in astrocytoma

9

ERB2

- HER2/neu
- amplification of epidermal growth factor seen in breast cancer

10

Ret

- growth factor
- point mutation seen in MEN 2A, 2B and sporadic medullary carcinoma of the thyroid

11

Kit

- stem cell growth factor point mutation seen in GIST

12

Ras

- GTP binding point mutation- GAP usually turns off Ras but this is mutated to turn it on
- seen in carcinomas, melanomas and lymphomas

13

ABL

- tyrosine kinase translocation t9;22 with BCR
- CML and some ALL

14

C-myc

- transcription factor regulator, t(8;14)
- Burkitt lymphoma

15

Chromosome 14 has what?

the Ig heavy chain = always expressed

16

N-myc

amplification of transcription factor
- seen in neuroblastoma

17

L-myc

- amplification of transcription factor
- seen in small cell lung carcinoma

18

Cyclin D1

- cell cycle regulator, translocation t11;14
- cyclin D allows G1 -> S
- Mantle cell lymphoma

19

CDK4

amplification of cell cycle regulator
- seen in melanoma