Neoplasia Flashcards Preview

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Flashcards in Neoplasia Deck (29)
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1
Q

-oma usually connotes a benign tumor except

A

seminoma
lymphoma
melanoma
hepatoma

2
Q

___ is a tumor-like condition where an ectopic tissue is cytologically and architecturally normal

A

Choristoma/Ectopia

3
Q

____ is the first node in a regional lymphatic basin that receives lymph flow from the primary tumor

A

sentinel lymph node

4
Q

Most common CA in children

A

ALL

5
Q

Most common CA in males

A

prostate

6
Q

most common CA in females

A

breast

7
Q

Most common CA that cause mortality

A

lung CA

8
Q

Type of growth factor receptor that is encoded by oncogenes

A

Tyrosine Kinase

9
Q

[name the protooncogene]

Polycythemia vera, essential thrombocytosis, primary myelofibrosis

A

JAK 2

10
Q

[name the protooncogene]

Hairy cell leukemia

A

BRAF

11
Q

[name the protooncogene]

Burkitt lymphoma, Neuroblastoma

A

MYC

12
Q

[name the protooncogene]

Glioblastoma
Melanoma

A

CDK4

13
Q

[tumor suppressor gene]
G1-S phase cell cycle checkpoint

Normally, active when hypophosphorylated

A

Rb: becomes hyperphosphorylated –> inactivated

“governor of the cell”

14
Q

[tumor suppressor gene]

this monitors the stress in the cell

activated by: anoxia, inappropriate signalling by mutated oncoproteins, DNA damage

A

p53:

“Guardian of the genome”

15
Q

Liver fluke infection that cause cholangiocarcinoma

A

Chlonorchis sinensis

Opintorchis viverrini

16
Q

HHV 5 =

A

CMV

17
Q

HHV 4

A

EBV

HHV 1 = HSV

18
Q
HHV 1 =
HHV 2 = 
HHV 3
HHV 4 
HHV 5
HHV 6
HHV 7
HHV 8
A
HHV 1 = HSV 1
HHV 2 = HSV 2
HHV 3 = VZV
HHV 4 = EBV
HHV 5 = CMV
HHV 6 = Roseola
HHV 7 = Roseola-like
HHV 8 = Kaposi
19
Q

CA associated in exposure to PVC pipes

A

Liver Angiosarcoma

Vinyl chloride in PVC pipe

20
Q

[paraneoplastic syndrome]

Cushing syndrome due to excessive ACTH or ACTH-like substances

A

Small cell lung CA
Pancreatic CA
Neural tumors

21
Q

[paraneoplastic syndrome]

SIADH due to increased ADH or ANP

A

Small cell lung CA
Oat cell lung CA
Intracranial Lung CA

22
Q

[paraneoplastic syndrome]

Hypercalcemia due to increased PTHrP, TGF alpha, TNF, IL-1

due to cancer-induced bone disease

A

Squamous cell CA
Breast CA
Renal Cell CA

23
Q

aside from thymic neoplasms, myasthenia gravis is associated with what CA

A

bronchogenic carcinoma

24
Q

[paraneoplastic syndrome]

This dermatologic manifestation is due to increased production of EGF. Associated with gastric CA, lung CA, uterine CA

A

acanthosis nigricans

25
Q

[paraneoplastic syndrome]

Hypertrophic osteoarthritis
Clubbing of finger

A

bronchogenic CA

Thymic neoplasm

26
Q

[paraneoplastic syndrome]

migratory thrombophlebitis due to tumor products that activate clotting

A

pancreatic CA

bronchogenic CA

27
Q

In tumor grading ang staging,

this is more reflective of biologic behavior of cancer

A

cancer stage

28
Q

Abnormalities in tumor lysis syndrome

A

hyperkalemia
hyperphosphatemia
hyperuricemia
hypocalcemia

29
Q

The most common clinical consequence of tumor lysis syndrome.

A

urate nephropathy