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2MB Musculoskeletal > Muscle Disease > Flashcards

Muscle Disease Flashcards

1
Q

What is the difference between polymyositis and dermatomyositis?

A

Dermatomyositis = polymyositis + skin changes

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2
Q

The risk of malignancy increases with polymyositis and dermatomyositis. True/False?

A

True

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3
Q

List the classic presenting MSK features of poly/dermato -myositis

A

Muscle weakness that worsens over months
Symmetrically affected
Myalgia
Difficulty with daily tasks

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4
Q

List investigations for poly/dermato -myositis

A 
Inflammatory markers
Muscle enzyme (CK)
Autoantibodies
Electrolytes
Electromyography
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5
Q

Which antibodies are associated with poly/dermato -myositis?

A

ANA

Anti-Jo-1

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6
Q

What is the definitive test for poly/dermato -myositis?

A

Muscle biopsy

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7
Q

List the main treatment for poly/dermato -myositis

A

Steroids
Immunosuppression (methotrexate, azathioprine)
Ciclosporin
Rituximab

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8
Q

What is the steroid usually used for poly/dermato -myositis?

A

Prednisolone 40mg daily

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9
Q

Inclusion body myositis is more common in males. True/False?

A

True

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10
Q

Is muscle weakness in inclusion body myositis usually symmetrical or asymmetrical?

A

Asymmetrical

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11
Q

CK levels in inclusion body myositis are increased to a lesser fold compared to poly/dermato -myositis. True/False?

A

True

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12
Q

Inclusion body myositis is associated with anti-Jo-1 antibody. True/False?

A

False

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13
Q

Polymyalgia rheumatica is associated with which arteritic disease?

A

Giant cell arteritis

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14
Q

Muscle weakness if a feature of polymyalgia rheumatica. True/False?

A

False

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15
Q

List the common features of polymyalgia rheumatica

A

Morning stiffness - can’t get out of bed
Fatigue
Anorexia
Reduced movement

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16
Q

What is the mainstay of treatment for polymyalgia rheumatica?

A

Low dose steroid - usually rapid/dramatic response

17
Q

What is the commonest cause of chronic MSK pain?

A

Fibromyalgia

18
Q

Is fibromyalgia inflammatory?

A

No

19
Q

Fibromyalgia is commoner in which sex?

A

Women

20
Q

List some clinical features of fibromyalgia

A 
Broken sleep
Pain all over body
Pins and needles
Headaches
Depression
Tenderness on soft tissues

2MB Musculoskeletal (19 decks)

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