Multiple organ dysfunction syndrome Flashcards Preview

Y3 - Conditions and prodedures > Multiple organ dysfunction syndrome > Flashcards

Flashcards in Multiple organ dysfunction syndrome Deck (4)
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1
Q

Define

A

• A clinical syndrome characterised by the development of progressive and potentially reversible physiologic dysfunction of 2 or more organs or organ systems that is induced by a variety of insults, including sepsis.

2
Q

What are the risk factors?

A

• Usually results from:
o Infection
o Injury
o Hypoperfusion
o Hypermetabolism
• This primary cause can trigger a systemic inflammatory response (sepsis or SIRS)
• MODS is the final stage in a continuum beginning with SIRS + infection:
o SIRS + infection –> sepsis –> severe sepsis –> MODS

3
Q

What are the presenting symptoms and signs?

A

o Stage 1 - increased volume requirements, mild respiratory alkalosis, oliguria, hyperglycaemia, increased insulin requirements
o Stage 2 - tachypnoea, hypocapnia, hypoxaemia, moderate liver dysfunction and haematologic abnormalities
o Stage 3 - shock, azotaemia (high nitrogen in the blood), acid-base disturbance, significant coagulation abnormalities
o Stage 4 - vasopressor dependent, oliguria or anuria, development of ischaemic colitis and lactic acidosis

4
Q

What are the appropriate investigations?

A
  • Monitor vital signs

* ABG may be necessary to look at hypoxaemia, lactic acidosis etc.