Multi-System Auto-Immune Disease Flashcards Preview

Systems: MSK AB > Multi-System Auto-Immune Disease > Flashcards

Flashcards in Multi-System Auto-Immune Disease Deck (59)
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1

What is the diagnosis for someone presenting with:
-Mylagia/arthralgia
-Episcleritis
-Sinusitis
-Renal failure

Wegner's granulomatosis

2

What is the diagnosis for someone presenting with:
-Mylagia/arthralgia
-Skin rash
-Pleurisy
-CVA

Lupus

3

What is the diagnosis for someone presenting with:
-Mylagia/arthralgia
-Skin thickening
-GORD
-Pulmonary hypertension

Scleroderma

4

What is the diagnosis for someone presenting with:
-Mylagia/arthralgia
-Sicca
-Skin rash
-Neuropathy

Sjorgen's syndrome

5

Give examples of autoimmune connective tissue diseases.

-Systemic Lupus Erythematosus
-Scleroderma
-Sjogren’s syndrome
-Auto-immune myositis
-Mixed connective tissue disease

6

Give examples of autoimmune systemic vasculitis?

-Giant cell arteritis
-Granulomatosis polyangiitis (Wegeners)
-Microscopic polyangiitis
-Eosinophilic granulomatosis polyangiitis (Churg-Strauss)

7

How are multisystem autoimmune diseases diagnosed?

-Cardinal clinical features: History & Exam
-Immunology
-Imaging
-Tissue
-Exclusion of differential diagnosis

8

What can mimic multisystem autoimmune diseases?

-Drugs such as cocaine, minocycline, PTU
-Infections including HIV, endocarditis, Hepatitis and TB
-Malignancy, in particular lymphoma
-Cardiac myxoma
-Cholesterol emboli
-Scurvey

9

What is the epidemiology of SLE?

-UK Prevalence: 28/100,000
-UK incidence: 4/100,000
-F:M 9:1
-Onset: 15-50 years
-Significant ethnic diversity: Afro-Caribbean> Asian> Caucasian

10

How can SLE affect the skin and hair?

-Butterfly rash
-Photosensitivity
-Alopecia
-Vasculitis
-Purpura
-Urticaria

11

How can SLE affect the nervous system?

-Fits
-Hemiplegia
-Ataxia
-Peripheral neuropathy
-Cranial nerve lesions

12

How can SLE affect the heart and chest?

-Pericarditis
-Endocarditis
-Aortic valve lesions
-Pleurisy
-Pleural effusion
-Lung fibrosis

13

How can SLE affect the MSK system?

-Myopathy
-Aseptic necrosis of the hip
-Arthritis in small joint

14

How can SLE affect the blood?

-Anaemia (nomochromic normocytic Coombs test positive)
-Leukopenia
-Thrombocytopenia

15

How can SLE affect a person in general?

-Fever
-Depression
-Raynaud's phenomenon
-Abdominal pain

16

What is the classification criteria for SLE?

Any 4
-Malar rash (butterfly rash)
-Discoid rash (raised, scarring, permanent marks, alopecia)
-Photosensitivity
-Oral ulcers
-Arthritis (2 joints at least)
-Serositis (pleurisy or pericarditis)
-Renal (significant proteinuria or cellular casts in urine)
-Neurological (unexplained seizures or psychosis)
-Haematological (low WCC, platelets, lymphocytes, haemolytic anaemia)
-Immunological (anti ds-DNA, SM, cardiolipin, lupus anticoagulant, low complement)
-ANA

17

What is the earliest sign of kidney involvement in SLE?

Blood and protein on urine dipstick

18

What is scleroderma characterised by?

Thickening of the skin

19

What is the epidemiology of scleroderma?

-UK Prevalence: 24/100,000
-UK Incidence: 10/1,000,000
-Onset: 30-50 years
-F:M 3:1

20

What is the name for scleroderma limited?

Crest syndrome

21

What are the features of Crest syndrome?

-Calcinosis
-Raynaud's
-Oesophageal dysmotility
-Sclerodactyly
-Telangiectasia

22

What is a possible complication of limited scleroderma?

Pulmonary hypertension

23

What are the possible outcomes of diffuse scleroderma?

-Pulmonary fibrosis
-Renal crisis
-Small bowel bacterial overgrowth

24

What is the epidemiology of Sjogren's syndrome?

-Prevalence: 1 in 100
-Incidence: 4 in 100,000
-Onset: 40-50yrs
-F:M 9:1

25

How can sjogren's syndrome affect the GI system?

-Dysphagia
-Abnormal oesophageal motility

26

How can sjogren's syndrome affect the respiratory system?

Interstitial lung disease

27

How can sjogren's syndrome affect the CNS?

-Fits
-Hemiplegia
-Ataxia
-Cranial nerve lesions

28

How can sjogren's syndrome affect the renal system?

Renal tubular acidosis

29

How can sjogren's syndrome affect the skin?

-Palpable purpura
-Raynaud's syndrome

30

How can sjogren's syndrome affect the joints?

Arthralgia