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Flashcards in [MS] Allergy Deck (19)
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1
Q

What is the function of Class I HLA antigens?

A

Present non-self (cancer/viruses) to CD-8+ cells

2
Q

What is the function of Class II HLA antigens?

A

Found on macrophages to present antigens to CD-4+ cells

3
Q

What is the inheritance pattern of the most common form of SCID?

A

X-linked (IL-2R-gamma)

4
Q

What is a common radiographic finding for children with SCID?

A

Absence of the thymic shadow

5
Q

What are the symptoms seen with the Omenn Syndrome-variant of SCID?

A
Severe Erythroderma
Marked Eosinophilia
Diarrhea
Hepatosplenomegaly
Failure to Thrive
6
Q

What is the mnemonic to help remember Wiskott-Aldrich syndrome?

A

Eczema
X-Linked
Immunodeficiency
Thrombocytopenia (with small platelet size)

7
Q

What are the characteristic findings of Ataxia-Telangiectasia?

A
Autosomal recessive
Cerebellar ataxia
Oculocutaneous telangiectasia
Increased risk of cancer
Elevated alpha-fetoprotein
Sinopulmonary disease with bronchiectasis
8
Q

What is the chromosomal abnormality of DiGeorge syndrome?

A

Deletion of 22q11.2

9
Q

What are the clinical findings associated with DiGeorge syndrome?

A
Craniofacial anomalies (micrognathia, hypertelorism, shortened philtrum, low-set ears)
Cardiac anomalies (tetrology of Fallot, VSD, transposition)
Subclinical hypoparathyroidism
10
Q

What is the genetic defenct found in Bruton’s Agammaglobulinemia?

A

Xq22 mutation

11
Q

What is the most severe infection patients with Duncan syndrome could get?

A

EBV infection as it causes lymphoproliferative disease

12
Q

What are the common clinical findings assocaited with type I leukocyte adhesion defect?

A

Delayed umbilical cord separation and cigarette paper scarring of the skin

13
Q

What are the common clinical manifestations of Job’s syndrome (Hyper IgE)?

A

Eczema, delayed dental exfoliation, cold abscesses, and post-infectious pulmonary cysts

14
Q

What are the common clinical findings of Chediak-Higashi syndrome?

A

Recurrent sinopulmonary infections, partial oculocutaneous albinism, and giant neutrophil granules

15
Q

What future problem are deficiences of C1/C2/C4 associated with?

A

Rheumatologic problems such as SLE

16
Q

What types of infections are associated with C5-C9 deficiencies?

A

Invansive pneumococcal and meningococcal disease

17
Q

What is the first test to perform when you suspect a complement deficiency?

A

CH50

18
Q

What is the cause of Hereditary Angioedema?

A

Defect in the C1 inhibitor with secondarily decreased C4 levels

19
Q

What food allergies are associated with Latex allergies?

A

Papaya, Kiwi, Bananas, Potatoes, Avocados, Chestnuts, and Tomatoes