Mosquitoes and Rabies Lecture Flashcards Preview

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Flashcards in Mosquitoes and Rabies Lecture Deck (16)
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1

-Uniformly fatal viral encephalitis of mammals
-Transmitted by saliva of infected animals

*While most mammals can be infected, only a few species serve as reservoir hosts

Rabies

2

virus lives in saliva, brain, spinal cord of infected animals
*Spread when infected animals bite or scratch animal/human

**NOT spread by petting rabid animal, contacting dried saliva, blood, urine, or feces from rabid animal

Rabies

3

What animal is the principal vector for human rabies cases in the US

Bats

4

Overt signs of rabies will always develop within ___ days of presence of virus in saliva

10

5

Incubation period of human rabies

4-12 weeks

6

Prodrome (2-10 days): paresthesias at site of wound, nonspecific constitutional illness (fever, headache, anorexia)

Rabies

7

Acute Neurologic Phase (2-7 days): Signs of encephalitis (mental status changes, paresis and paralysis, hyperactivity, aphasia), hypersalivation, myoclonus, agitation/anxiety.

Rabies

8

What stage of rabies consists of: coma, dysrhythmias, DIC, death

Late stage

9

How many documented cases of human rabies survival are there? (all had some pre or post exposure vaccination)

6!

10

Decrease exposures to potentially rabid animals

Pre-exposure vaccination for high-risk

Post-exposure immunization with vaccine and immune globulin (HRIG)

Ways to prevent human rabies

11

Human Diploid Cell Vaccine (HDCV)

Purified Chick Embryo Vaccine (PCEC)

Rabies Vaccine Adsorbed (RVA)

Cell culture vaccines for rabies

12

Local reactions
Mild systemic reactions
Anaphylaxis (rare!)
Serum sickness-like

Adverse reactions associated w rabies vaccines

13

Passive temporary protection (immediate)

Derived from human plasma

Heat and chemical inactivation

Anaphylaxis and significant adverse effects are rare

Human Rabies Immune Globulin (HRIG)

14

Persons bitten by animal known to be rabid

Persons bitten by an animal likely to be rabid but unavailable for testing

Persons bitten by a raccoon, skunk, fox, bat or other carnivore that cannot be tested

Certain other “nonbite” exposures

Need PEP (post exposure for rabies)

15

-cleansing and irrigation of wound

-vaccine (IM deltoid) on days 0,3 7, 14

-HRIG infiltrated in and around wound

Protocol for those exposed to rabies IF NOT PREVIOUSLY VACCINATED

16

Cleansing and irrigation of wound

Vaccine (IM deltoid) on days 0 and 3 only

Do NOT give HRIG

Protocol for those exposed to rabies IF PREVIOUSLY VACCINATED