Monoclonal Antibodies Flashcards

1
Q

Alemtuzumab (target and use)

A

Target: CD52
Use: CLL

aLYMtuzumab - chronic LYMphocytic leukemia

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2
Q

Bevacizumab (target and use)

A

Target: VEGF
Use: colorectal cancer, renal cell carcinoma, neovascular age-related macular degeneration

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3
Q

Cetuximab (target and use)

A

Target: EGFR
Use: stage IV colorectal cancer, head and neck cancer

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4
Q

Rituximab (target and use)

A

Target: CD20
Use: B-cell non-Hodgkin lymphoma, CLL, RA, ITP

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5
Q

Trastuzumab (target and use)

A

Target: HER-2/neu
Use: Breast cancer

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6
Q

Adalimumab and Infliximab (target and use)

A

Target: TNF-alpha (soluble)
Use: IBD, RA, ankylosing spondylitis, psoriasis

NOTE: Etanercept is a TNF-alpha receptor NOT monoclonal antibody

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7
Q

Eculizumab (target and use)

A

Target: complement protein C5
Use: paroxysmal nocturnal hemoglobinuria (DAF/GPI link deficiency)

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8
Q

Natalizumab (target and use)

A

Target: alpha4-integrin
Use: mutliple sclerosis, Crohn’s disease

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9
Q

Special consideration with Natalizumab

A

alpha4-integrin important for WBC adhesion

risk of PML in patients with JC virus

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10
Q

Abciximab (target and use)

A

Target: platelet glycoproteins IIb/IIIa
Use: antiplatlet agent for prevention of ischemic complications in patients undergoing percutaneous coronary intervention

2 x 3 = abSIXimab

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11
Q

Denosumab (target and use)

A

Target: RANKL
Use: osteoporosis (inhibits osteoclast maturation)

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12
Q

Digoxin immune Fab (target and use)

A

Target: Digoxin
Use: antidote for digoxin toxicity

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13
Q

Omalizumab (target and use)

A

Target: IgE
Use: Allergic asthma (prevents IgE binding to FceRI)

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14
Q

Palivizumab (target and use)

A

Target: RSV F protein
Use: RSV prophylaxis for high-risk infants

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15
Q

Ranibizumab (target and use)

A

Target: VEGF
Use: neovascular age-related macular degeneration

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