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2MB Endocrinology > MODY > Flashcards

Flashcards in MODY Deck (11)
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1
Q

What does MODY stand for?

A

Mature onset diabetes of the young

2
Q

What inheritance pattern does MODY usually follow?

A

Autosomal dominant

3
Q

Is MODY insulin-dependent?

A

No

4
Q

What is the age of onset of MODY?

A

Before age of 25

5
Q

What are the 2 main distinct types of MODY?

A

Transcription factor mutations (HNF-1alpha)

Glucokinase mutation

6
Q

At what age does glucokinase mutation related MODY onset?

A

Birth

7
Q

At what age does transcription factor mutation related MODY onset?

A

Adolescence/young adulthood

8
Q

Glucokinase mutation related MODY involves unstable hyperglycaemia. True/False?

A

False

Stable hyperglycaemia

9
Q

Glucokinase mutation related MODY has better prognosis than transcription factor mutation related MODY. True/False?

A

True

10
Q

Neonatal diabetes requires insulin treatment within the first 3 months of life. True/False?

A

True

11
Q

Which drug class is good for transcription factor mutation related MODY?

A

Sulphonylureas