Midazolam Flashcards

0
Q

Imidazole ring

A

After soluble at a pH less than 4

Closes upon injection and becomes highly lipid soluble

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1
Q

Potency

A

2-4 times more potent than diazepam

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2
Q

Protein bound

A

96-98%

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3
Q

Lipid soluble

A

Rapid uptake by the brain

Redistribution and re-uptake

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4
Q

VD

A

1-1.5 L/kg

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5
Q

Clearance

A

6-8 ml/kg/min

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6
Q

Elimination half life

A

1-4 hours

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7
Q

Oxidative hydroxylation

A

In the liver

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8
Q

Glucoronide conjugation

A

In the kidneys

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9
Q

Excreted

A

Urine

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10
Q

Metabolizes

A

Minimally active

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11
Q

H2 receptor antagonists added

A

Not affected

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12
Q

Cardiac response

A

Minimal and similar to NaP

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13
Q

Ventilation

A

Depressed with 0.15 mg/kg dose

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14
Q

Renal failure

A

Kemal effects on half life, VD, and clearance

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15
Q

CBF

A

Dose related decrease in CBF and CMRO2

16
Q

Placenta

A

Crosses the U-P membrane