MHC B cells Flashcards Preview

Immunology > MHC B cells > Flashcards

Flashcards in MHC B cells Deck (9)
Loading flashcards...
1
Q

What is signaling initiated by

A

Cross linking of adjacent BCR by antigens

2
Q

What is B-cell signaling essential for

A

Proliferation and differentiation into Ig- secreting plasma cells

3
Q

Is a single B-cell sufficient for activation

A

No

4
Q

What receptors are cross-linked for Bcell signaling initiation

A

BCR and Fc receptor

5
Q

What’s the second signal to B cell

A

CD40-CD40L

6
Q

What is the first signal to the b cell

A

BCR cross-linking
Increased CD40 expression
Specific response

7
Q

Full steps for activation of T and B cells

A

1st signal to B cell- antigen on antigen receptor
Processing of antigen- Makes B7 which will become the 2nd signal to T cell
1st signal to T cell- B cell Presents antigen to T cell
2nd signal to B cell- T cell presents CD40L to B cell
T cell makes IL-4 which goes to the T cell

8
Q

What happens when B cell is activated

A

Divide, mature, produce antibody

9
Q

What are ITAMs

A

parts of proteins in intercellular domain, when they get together they create….something