Metabolic pathways and ATP production II Flashcards Preview

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Flashcards in Metabolic pathways and ATP production II Deck (8)
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1
Q

What are the products of one turn of the TCA cycle?

A

3 x NADH
1 x FADH2
1 x GTP
2 x CO2

2
Q

Where are the Krebs’ Cycle enzymes found?

A

Mitochondrial Matrix

3
Q

Which Krebs’ Cycle enzyme is not found in this location?

A

Succinate Dehydrogenase

4
Q

What happens in Transamination?

A

An amine group is transferred between an amino acid and a keto acid to generate a new amino acid and keto acid (the basis of the malate-aspartate shuttle)
EXAMPLE: alanine + alpha-ketoglutarate  pyruvate + glutamate (enzyme = alanine aminotransferase)

5
Q

What are the two ways of electrons from NADH entering the mitochondrial matrix? Where are these two transport mechanisms found?

A

Glycerol Phosphate Shuttle – skeletal muscle, brain

Malata-Aspartate Shuttle – liver, kidney, heart

6
Q

Describe the glycerol phosphate shuttle.

A

Cytoplasmic glycerol-3-phosphate dehydrogenase transfers electrons from NADH to dihydroxyacetone phosphate converting it to glycerol-3-phosphate Glycerol-3-phosphate is converted by mitochondrial glycerol-3-phosphate back into Dihydroxyacetone phosphate and the electrons are passed via FAD to coenzyme Q

7
Q

What different types of reactions are NADPH and NADH involved in?

A
NADPH = Anabolic 
NADH = Catabolic
8
Q

What are the components involved in the malate-aspartate shuttle?

A

Malate (in)
Alpha-ketoglutarate (out) Oxaloacetate (converted from malate)
Glutamate (in)
Aspartate (out)