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Flashcards in Metabolic 3 Deck (3)
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1
Q

Outline the hypermetabolic responses to injury

A
  • Increased blood pressure & heart rate
  • Peripheral insulin resistance
  • Increased protein and lipid catabolism
  • Increased resting energy expenditure
  • Increased body temperature
  • Total body protein loss
  • Muscle wasting
  • Acute-phase protein response
2
Q

What are the endocrine complications that occur during starvation? (adrenal)

A
  • Increased HPA activity
  • Stress of chronic starvation

High cortisol (glucocortcoid)

Breakdown of protein (muscle, collagen) to glucose & urea

Loss of collagen: Osteopenia
Loss of muscle: Weakness

3
Q

What are the endocrine complications that occur during starvation? (thyroid)

A

Sick euthyroid pattern:
TSH low-normal, FT4 low-normal, FT3 low

Due to chronic undernutrition
- Decreased metabolic rate

Decreased conversion FT4 to FT3 (low)

TSH & FT4 levels: low normal or low

Reduced metabolic rate