Flashcards in Mechanism of Psychotropic Drug Action Deck (12)
What % of the UK population take antidepressants?
Describe the "positive" and negative" symptoms of Schizophrenia
Occur during episodes, i.e. hallucinations, delusions, etc
Occur and accumulate over time. Lack of motivation, reduced speech, emotion, withdrawal
Describe the pathophysiology of Bipolar disorder
Starts in young adult life, episodes of depression with manic episodes
Noradrenaline is particularly released by which set of neurons in the Brainstem?
Serotonin is particularly released by which set of neurons in the Brainstem?
Once a GABA receptor is stimulated, what ions flow across the post-synaptic membrane, causing hyperpolarisation?
Anti-psychotic drugs antagonist which receptors?
D2 (Dopamine) receptors
Give one example of a first generation D2 antagonising anti-psychotic drug
Give two examples of a second generation D2 antagonising anti-psychotic drug
What is the mechanism of action for Tricyclic Antidepressants?
Block noradreline uptake
Block serotonin uptake
What is the mechanism of action of Mono-amine oxidase inhibitors?
Block the action of MAO in nerve terminals, increasing NA, 5-HT, DA availability