Mechanism of Psychotropic Drug Action Flashcards Preview

Medicine, Year 1 Block 6 (Psychological Medicine) > Mechanism of Psychotropic Drug Action > Flashcards

Flashcards in Mechanism of Psychotropic Drug Action Deck (12)
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1

What % of the UK population take antidepressants?

7%

2

Describe the "positive" and negative" symptoms of Schizophrenia

Positive symptoms:
Occur during episodes, i.e. hallucinations, delusions, etc

Negative symptoms:
Occur and accumulate over time. Lack of motivation, reduced speech, emotion, withdrawal

3

Describe the pathophysiology of Bipolar disorder

Starts in young adult life, episodes of depression with manic episodes

4

Noradrenaline is particularly released by which set of neurons in the Brainstem?

Locus coerueus

5

Serotonin is particularly released by which set of neurons in the Brainstem?

Raphe Nuclei

6

Once a GABA receptor is stimulated, what ions flow across the post-synaptic membrane, causing hyperpolarisation?

Chloride, Cl-

7

Anti-psychotic drugs antagonist which receptors?

D2 (Dopamine) receptors

8

Give one example of a first generation D2 antagonising anti-psychotic drug

Haloperidol

9

Give two examples of a second generation D2 antagonising anti-psychotic drug

Olanzapine
Risperidone

10

What is the mechanism of action for Tricyclic Antidepressants?

Block noradreline uptake
Block serotonin uptake

11

What is the mechanism of action of Mono-amine oxidase inhibitors?

Block the action of MAO in nerve terminals, increasing NA, 5-HT, DA availability

12

What is the mechanism of action for Benzodiazepines?

Bind to a site on the GABA receptor, potentiating the effects of GABA ie. the GABA causes more Cl- flux and more inhibition