Amiodarone
Class III anti-arrthymic
Inhibits Na and K activated myocardial adenosine triphosphate- prolongs duration of ventricular and atrial muscle action.
Prolongs myocardial cell action potential duration and refractory period as it’s a non-competitive alpha and beta adrenergic inhibitor
Relaxes vascular smooth muscle, reduces peripheral resistance (afterload)
SA and AV node= increases refractory period via K and Na and slows intra cardiac conduction
Adenosine
A nucleotide
Slows conduction through the AV node and can interrupt re-entry pathways
Activates purine receptors on cell surface
Relaxes smooth muscle by inhibiting slow inward calcium channel currents and activation of adenylate cyclase
Negative inotrope effect - potent vasodilator (except renal afferent and hepatic), decreases HR ( reflex increases HR), mild reduction in BP
Propofol
Sedative-hypnotic agent for use in the induction and maintenance of anaesthesia
A positive modulation of the inhibitory function of GABA through GABA-A receptors
Emulsion
Adult 1-2.5 mg/kg
Suxamethonium
Skeletal muscle relaxant
Acts in 30 seconds, duration 3-5 minutes
Adjunct to GA to facilitate tracheal intubation and to relax skeletal muscle during surgery
A persistent depolarisation of the neuromuscular junction- mimics the effect of acetylcholine but without being rapidly hydrolysed by acetylcholine esterase.
1-1.5 mg/kg
Remifentanil
Opioid agonist u-opioid
Rapid onset and peak and ultra short duration of action
Given 1min before induction as may reduce undesirable hypertension and tachycardia
Improves intubating condition
1-2mg/kg
In obstetrics can cause neonatal infant respiratory depression
Sevoflurane
Halogenated ether used for induction and maintenance of GA
Induces muscle relaxation and reduces pain sensitivity