MDS, MPNs, Lymphomas, and Plasma Cell Malignancies Flashcards Preview

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Flashcards in MDS, MPNs, Lymphomas, and Plasma Cell Malignancies Deck (85)
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1

Features of MDS (2)

Ineffective hematopoiesis, Increased risk of transformation to AML

2

Two scenarios of MDS

Idiopathic (primary), Therapy-related (secondary

3

Hypolobation of mature neutrophils (including bilobed nuclei: pseudo-Pelger-Huet cells), hypogranularity of cytoplasm

Dysgranulopoiesis

4

2 reasons for the frequent occurrence of splenomegaly and hepatomegaly in patients with MPNs

Sequestration of excess blood cells, extramedullary hematopoiesis

5

3 possible negative end points for MPNs

Transformation to acute leukemia, Transformation to MDS, Excessive marrow fibrosis (resultant marrow failure)

6

4 Causes of Myelodysplasia that may mimic MDS

drugs, deficiency of B12, folate, or other nutrients, viral infection, toxin exposure

7

BCL1 is characteristic of _____.

Mantle Cell Lymphoma

8

BCL2 is characteristic of ______.

Follicular Lymphoma

9

CHL: both sides of diaphragm, lack collagen bands, EBV+ (75%)

Mixed Cellularity CHL

10

CHL: found in children and older patients

Mixed Cellularity Hodgkin lymphoma

11

CHL: least common of 4 subtypes, usually EBV+, numerous RS cells that may appear anaplastic and bizarre

Lymphocyte Depleted CHL

12

CHL: most common subtype

Nodular Sclerosis HL

13

CHL: nodular growth pattern with residual germinal centers, RS cells present but rare

Lymphocyte Rich CHL

14

CHL: predominates in young adults, especially females

Nodular Sclerosis HL

15

CHL: thickened lymph node capsule with broad bands of collagen and nodular areas surrounded by broad collagen

Nodular Sclerosis HL

16

CLL/SLL is more common in ______ (sex).

males (2:1)

17

CLL/SLL is most common in ______ (demographic).

older adults (Median age: 65)

18

Cytogenetic findings in MDS (5)

Monosomy 7; Deletion 7q; Monosomy 5; Deletion 5q; Trisomy 8

19

Low Grade MDS: Anemia, increased platelets, and distinctive megakaryocytes with small, round, non-lobated nuclei

Isolated Deletion of 5q

20

Low Grade MDS: Good prognosis, median survival >5 years

Refractory Cytopenia with Unilineage Dysplasia

21

Low Grade MDS: Median survival 2.5 years, 10% transformation to AML in 2 years

Refractory Cytopenia with Multilineage Dysplasia

22

Low Grade MDS: myeloblasts account for less than __% of marrow cells and less than __% of peripheral blood cells

5; 2

23

MDS is most common in ______ (demographic)

older adults

24

Megakaryocytes with hypolobated or non-lobated nuclei, often hyperchromatic nuclei, often megakaryocytes with small size

Dysmegakaryopoiesis

25

Most common cause of death in polycythemia vera patients, including locations (3): _____

Thrombosis (Mesenteric vein, Splenic vein, Portal vein)

26

Most common leukemia in the western world

Chronic Lymphocytic Leukemia (CLL)

27

MPN Genetic Findings: BCR-ABL1 fusion gene on der22

Chronic Myelogenous Leukemia

28

MPN Genetic Findings: JAK2 mutations in 50% of cases

Polycythemia Vera, Primary Myelofibrosis, and Essential Thrombocytopenia

29

MPN Morphology: clusters of large bizarre megakaryocytes followed by reticulin fibrosis with loss of marrow space

Primary Myelofibrosis

30

MPN Morphology: Dacryocytes in peripheral blood

Primary Myelofibrosis