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Derm 2020 > Lymphoma > Flashcards

Flashcards in Lymphoma Deck (31)
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1
Q

Cutaneous B cell lymphomas are lymphomas whose primary site is in the skin

A

True

2
Q

B cell lymphomas make up a minority of NHLs whose primary site is in the skin

A

False, majority

3
Q

What are poor prognostic factors of B cell lymphoma

A

Multifocal disease,
High serum level of LDH
Value of staging tumour burden in primary cutaneous MZL and primary cutaneous FCL has not been shown to have an impact on prognosis

4
Q

Solitary and grouped pink to plum coloured papules, plaques or tumours — aka “Crosti’s lymphoma”

A

True - primary cutaneous follicle centre lymphoma

5
Q

Primary cutaneous follicle centre lymphoma has recurrences up to 50% and commonly disseminates to LN or internal organs

A

False- Rarely disseminates

Recurrence rate correct

6
Q

Nodular and diffuse infiltrates occur in parts of the dermis with PCFCL

A

False - in the entire dermis, deeply extending to fat

7
Q

PCFCL epidermis usually involved on histo

A

False , usually spared

8
Q

IHC of PCFCL

A

BCl-6 positive, CD20, CD79a, PAX-5 all positive

NEGATIVE CD5, CD43, BCl-2 —> this is a major difference to follicular lymphomas arising fro WITHIN lymph nodes

9
Q

Prognosis excellent , LN/organ involvement rare w cutaneous marginal zone B cell lymphoma

A

True

10
Q

CMZBCL can be strongly associated with scabies

A

False - has been linked with Borrelia and can occur in areas affected by ACRODERMATITIS chronica atrophicans

11
Q

Trisomy 3 and 18 protect against CMZBCL

A

False- predispose

12
Q

Resolution of cutaneous marginal zone B cell lymphoma can result in anetoderma

A

True

13
Q

Cutaneous marginal zone B cell lymphoma often very tender

A

False - usually asymptomatic

14
Q

CMZBCL often ulcerate

A

False - rarely

15
Q

IHC of CMZBCL

A

CD20, CD79a, BCl-2 positive,

NEG BCl-6, CD5, CD10

16
Q

Primary cutaneous large B cell lymphoma occurs exclusively in elderly patients, predominantly men

A

False - predominantly women

17
Q

Primary cutaneous large B cell lymphoma, leg type IHC

A

CD20, CD79a, PAX-5, BCl-2 , MUM-1 , FOXP1

18
Q

CDKN2A mutations confer a better prognosis with PCLBCL

A

False -worse

19
Q

Intravascular diffuse large B cell lymphoma Often Present as macular erythematous and violaceous patches and plaques on trunk and thighs

A

False - indurated

20
Q

Intravascular diffuse large B cell lymphoma IHC

A

Positive for BCl-2, MUM-1 , FOX-P1

21
Q

Sezary syndrome triad

A

Circulating neoplastic T cells >1000/mcl
Erythroderma
With/without associated lymphadenopathy

22
Q

Transformed MF is characterised by moprphological change of small to medium sized atypical T lymphocytes to a large cell variant

A

True

23
Q

Need >75% of neoplastic T cell 4 x size of normal lymphocytes to diagnose large cell transformation

A

False, >25%

24
Q

Negative prognostic factors for MF

A
MAFIA BEL large sezary clone 30-
Male
Age
Folliculotropic variant
Initial treatment poor response
Advanced skin burden (T score)

B2 microglobulin
Eosinophilia
LDH

Large cell transformation
Sezary cell count high
Peripheral blood T cell clone detectable
CD30 neg

25
Q

Extracorporeal plasmapharesis is helpful for Sezary B0-B2

A

True

26
Q

Imiquimod is a treatment option for MF

A

true - 5% mon to fri for 12 weeks

27
Q

Alemtuzumab is an antiCD30 drug

A

False anti-CD52

28
Q

Folliculotropic MF displays overt epidermotropism

A

False - folliculotropic instead of epidermotropic

29
Q

Long term follow up is necessary for LyP as risk of progression to more aggressive lymphoma eg. P C-ACL, MF or Hodgkin in 20%

A

False <5%

30
Q

LyP spontaneously disappear over 3-8 weeks

A

True

31
Q

SC panniculitis like T cell lymphoma occurs in the trunk>extremities

A

False vice versa