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Flashcards in Lipoproteins Deck (25)
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1

What are the 5 types of lipoproteins?

Chylomicrons
VLDL -> IDL -> LDL
HDL

2

Where are chylomicrons formed?

Intestine

3

What do chylomicrons transport?

They bring dietary TAG from intestines to adipose and other tissues

4

Where are VLDLs formed?

Liver

5

What do VLDLs transport?

Transport synthesized TAG from the liver to adipose tissue and to skeletal and heart muscle

6

Where are IDLs formed?

They are formed via the processing of VLDLs in the circulation

7

What do IDLs transport?

Delivers remaining TAG and cholesterol to the liver.

8

Where are LDLs formed?

Formed via processing of IDLs in the circulation

9

What do LDLs transport?

Delivers cholesterol to the liver and other cells

10

Where are HDLs formed?

Mainly in the liver with some in the intestine.

11

What do HDLs transport?

They take cholesterol from peripheral cells and esterify it before transporting it to the liver

12

What are the other effects of HDLs?

Atheroprotective via enzymes such as paraoxonase that inhibit LDL oxidation

13

What is the main transport of exogenous lipid?

Chylomicrons

14

What is the main transport of endogenous lipid?

VLDL/IDL/LDL

15

What cofactor activates lipoprotein lipase?

Apo-CII

16

What is the function of lipoprotein lipase?

Hydrolyzes FAs of TAG

17

What is the cofactor that activates lecithin:cholesterol acyltransferase (LCAT)?

Apo-A1

18

What is the function of LCAT?

Esterification of cholesterol

19

What is the remnant receptor ligand that triggers chylomicron function?

Apo E

20

What is the LDL receptor ligand that triggers LDL receptor mediated protein (LRP) and LDL function?

Apo B-100

21

What is the HDL receptor ligand that triggers HDL function?

Apo A1

22

What are the structural proteins of chylomicrons?

B-48

23

What are the structural protein sod VLDLs?

B-100

24

What are the structural proteins of HDLs?

A-1

25

What are HDLs a store for?

Apo A-I
Apo C-II
Apo E

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