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Flashcards in Lipid Synthesis Deck (13)
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1

What is the first rate limiting enzyme of FA biosynthesis?

Acetyl-CoA Carboxylase

2

What hormone drive FA synthesis?

Insulin

3

What hormone drives formation of acetyl CoA and ketone bodies from FAs?

Glucagon and Epinephrine

4

What is the reaction of the enzyme Acetyl-CoA Carboxylase?

Converts acetyl CoA to malonyl CoA

5

What is the function of biotin in FA synthesis?

CO2 carrier

6

What transports acetyl groups for FA synthesis?

Citrate carries acetyl from the mitochondria to the cytoplasm

7

What is the allosteric activator of Acetyl-CoA Carboxylase?

Citrate

8

What are the allosteric inhibitors of Acetyl-CoA Carboxylase?

Palmitoyl CoA (it is the ultimate product of FA synthesis)

AMP

9

What is the only physiological inhibitor of rate limiting enzyme in fatty acid oxidation?

Malonyl CoA

10

What will increase the synthesis of Acetyl-CoA Carboxylase?

High Cabohydrate Diet
Fat Free Diet

11

What will inhibit the synthesis of Acetyl-CoA Carboxylase?

High Fat Diet
Fasting

12

What is the function of the fatty acid synthase complex?

Catalyzes the formation of FAs from 1 acetyl CoA and 7 malonyl CoA

13

What is the allosteric activator of the fatty acid synthase complex?

Fructose 1,6-bisphosphate

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