Lipid Synthesis

Question 1

What is the first rate limiting enzyme of FA biosynthesis?

Answer 1

Acetyl-CoA Carboxylase

Question 2

What hormone drive FA synthesis?

Answer 2

Insulin

Question 3

What hormone drives formation of acetyl CoA and ketone bodies from FAs?

Answer 3

Glucagon and Epinephrine

Question 4

What is the reaction of the enzyme Acetyl-CoA Carboxylase?

Answer 4

Converts acetyl CoA to malonyl CoA

Question 5

What is the function of biotin in FA synthesis?

Answer 5

CO2 carrier

Question 6

What transports acetyl groups for FA synthesis?

Answer 6

Citrate carries acetyl from the mitochondria to the cytoplasm

Question 7

What is the allosteric activator of Acetyl-CoA Carboxylase?

Answer 7

Citrate

Question 8

What are the allosteric inhibitors of Acetyl-CoA Carboxylase?

Answer 8

Palmitoyl CoA (it is the ultimate product of FA synthesis)

AMP

Question 9

What is the only physiological inhibitor of rate limiting enzyme in fatty acid oxidation?

Answer 9

Malonyl CoA

Question 10

What will increase the synthesis of Acetyl-CoA Carboxylase?

Answer 10

High Cabohydrate Diet

Fat Free Diet

Question 11

What will inhibit the synthesis of Acetyl-CoA Carboxylase?

Answer 11

High Fat Diet

Fasting

Question 12

What is the function of the fatty acid synthase complex?

Answer 12

Catalyzes the formation of FAs from 1 acetyl CoA and 7 malonyl CoA

Question 13

What is the allosteric activator of the fatty acid synthase complex?

Answer 13

Fructose 1,6-bisphosphate