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Flashcards in Lipid Metabolism Deck (23)
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1

What is the activated to mobilize FAs?

Hormone-sensitive trriacyglycerol lipase (HSTL)

2

How is HSTL activated?

Epinephrine activates a cAMP pathway that activates PKA and mobilizes FAs

3

What is perilipin?

It coats the fait droplet and it must be Pi by PKA for HSTL to translate to the surface of the fat droplet.

4

What hormone will inhibit HSTL activity?

Insulin

5

What is the effect of adrenal cortical and thyroid hormones on HSTL?

Thyroid hormones & adrenal cortical hormones are permissive. Although they do not activate the enzyme, their presence is required for normal activity.

6

What is the effect of prostaglandins on HSTL?

Inhibit

7

How are fatty acids carried in the blood?

Bound to albumin

8

How does mobilization of FA affect FA biosynthesis?

Inhibits as palmitoyl CoA allosterically inhibits acetyl CoA carboxylase

9

How does mobilization of FA affect beta-oxidation of FAs?

Increase as there is more substrate and malonyl CoA is not produced and it is the sole inhibitor of beta-oxidation

10

How does mobilization of FA affect ketone body formation?

Increase due to increased beta oxidation

11

How does mobilization of FA affect gluconeogenesis?

Increase as beta-oxidation will increase the ATP available.

12

How does mobilization of FA affect glycolysis?

Inhibited due to increase in ATP levels which will inhibit PFK-1

13

What is the major energy producing pathway in the body?

Beta-oxidation

14

What are good users of fatty acid in the body?

Adipose
Liver
Skeletal Muscle

15

What are poor users of fatty acids in the body?

Brain

16

What is the function of carnitine?

It transports long FA chains in to the mitochondria for beta-oxidation

17

What is the function of carnitine palmitoyl transferase I?

CPT-I is the rate limiting enzyme of beta-oxidation

18

What is the only inhibitor of CPT-I?

Malonyl CoA

19

Where are ketone bodies formed?

They are formed in the mitochondria when there is a high rate of beta-oxidation

20

Where is the only place that ketone bodies are made?

Liver

21

Where are ketone bodies used?

Brain and muscle

22

What is the rate limiting enzyme of ketone synthesis and where is it found?

HMG-CoA synthase. It is found only in the liver.

23

What is the enzyme of ketone utilization and where is it found?

Acetoacetate:succinyl CoA CoA transferase. It is NOT found in the liver and is in the mitochondria of brain and muscle.

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