Flashcards in Lipid Metabolism Deck (23)
What is the activated to mobilize FAs?
Hormone-sensitive trriacyglycerol lipase (HSTL)
How is HSTL activated?
Epinephrine activates a cAMP pathway that activates PKA and mobilizes FAs
What is perilipin?
It coats the fait droplet and it must be Pi by PKA for HSTL to translate to the surface of the fat droplet.
What hormone will inhibit HSTL activity?
What is the effect of adrenal cortical and thyroid hormones on HSTL?
Thyroid hormones & adrenal cortical hormones are permissive. Although they do not activate the enzyme, their presence is required for normal activity.
What is the effect of prostaglandins on HSTL?
How are fatty acids carried in the blood?
Bound to albumin
How does mobilization of FA affect FA biosynthesis?
Inhibits as palmitoyl CoA allosterically inhibits acetyl CoA carboxylase
How does mobilization of FA affect beta-oxidation of FAs?
Increase as there is more substrate and malonyl CoA is not produced and it is the sole inhibitor of beta-oxidation
How does mobilization of FA affect ketone body formation?
Increase due to increased beta oxidation
How does mobilization of FA affect gluconeogenesis?
Increase as beta-oxidation will increase the ATP available.
How does mobilization of FA affect glycolysis?
Inhibited due to increase in ATP levels which will inhibit PFK-1
What is the major energy producing pathway in the body?
What are good users of fatty acid in the body?
What are poor users of fatty acids in the body?
What is the function of carnitine?
It transports long FA chains in to the mitochondria for beta-oxidation
What is the function of carnitine palmitoyl transferase I?
CPT-I is the rate limiting enzyme of beta-oxidation
What is the only inhibitor of CPT-I?
Where are ketone bodies formed?
They are formed in the mitochondria when there is a high rate of beta-oxidation
Where is the only place that ketone bodies are made?
Where are ketone bodies used?
Brain and muscle
What is the rate limiting enzyme of ketone synthesis and where is it found?
HMG-CoA synthase. It is found only in the liver.