LFTs - Hepatic Fxn Panel

Question 1

Gamma-Glutamyl Transpeptidase (GGT)

Answer 1

• Determines source of Alkaline Phosphatase elevation

- Sometimes used as marker of alcohol consumption

Question 2

What indicates liver inflammation/hepatocellular damage?

Answer 2

↑ALT & ↑AST

Question 3

What is the pattern for cholestasis?

Answer 3

↑Alk Phos, ↑Direct, ↓urine Urobilinogen

Question 4

What indicates reduced liver fxn?

Answer 4

↑PT/INR, ↓Albumin

Question 5

What is the common cause of cholestasis or obstructive jaundice?

Answer 5

Choledocholithiasis

Question 6

What does choledocholithiasis present w/?

Answer 6

• Pain – biliary colic
• Jaundice
• Clay-colored stools
• Cola colored urine

Question 7

What does Gilbert Syndrome cause in lab test?

Answer 7

Elevation in indirect bilirubin

Question 8

What is Gilbert Syndrome?

Answer 8

• Benign condition

- Usually only seen in homozygotes

Question 9

What causes Gilbert Syndrome?

Answer 9

Defect in the promotor of the gene that encodes the enzyme uridine diphosphoglucuronate-glucuronosyltransferase 1A1 (UGT1A1), which is responsible for the conjugation of bilirubin w/ glucuronic acid

Question 10

What is Alkaline Phosphate derived from?

Answer 10

• Liver
• Bone
• Therefore, must follow up w/ GGT to determine source

Question 11

What does elevated GGT indicate?

Answer 11

Source = liver

Question 12

If GGT is normal, what does this indicate?

Answer 12

Source = Bone