LFTs for Hepatocellular Damage/Injury Flashcards Preview

Q4 Clin Lab II thyroid, rheum, coag, LFT, body fluids > LFTs for Hepatocellular Damage/Injury > Flashcards

Flashcards in LFTs for Hepatocellular Damage/Injury Deck (13)
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1
Q

AST is?

A

Enzyme released in response to injury of liver, heart, mm, kidney

2
Q

ALT is?

A

Enzyme released in response to injury of liver or kidney

3
Q

LDH is?

A

Enzyme released w/ injury or dz of many organs

LDH-5 specific to liver and skeletal mm

4
Q

Elevated AST/ALT most C w/ what conditions? (5)

A
EtOH
NASH/Fatty liver
Meds
Hepatitis
Hemochromatosis (Fe buildup)
5
Q

NAFLD test results?

A

↑AST/ALT

6
Q

Hemochromatosis tests? (3)

A

Serum Fe
TIBC
Ferritin

7
Q

Autoimmune Hepatitis test? (4)

A

↑AST/ALT
ANA
SMA
IgG

8
Q

α-1 Antitrypsin Deficiency tests? (2)

A

↑AST/ALT

↓α-1

9
Q

Wilson’s Dz tests? (3)

A

↑AST/ALT
↓Ceruplasmin
24 hr urine copper

10
Q

Hep A tests? (4)

A

↑AST/ALT
↑Alk Phos/Bilirubin
IgM anti-HAV + (acute infect)
IgG anti-HAV + (immunity)

11
Q

Hep B tests? (8)

A
↑AST/ALT
↑Alk Phos/Bilirubin
HBsAg + (active)
anti-HBs + (immun)
IgM anti-HBc + (acute inf)
IgG anti-HBc + (previous inf, now immune)
HBeAg (Infective)
anti-HBe (long term clearance)
12
Q

Hep C tests?

A

↑AST/ALT
↑Alk Phos/Bilirubin
anti-HCV + (past or ongoing)

13
Q

AST:ALT ratio tells us:

> 2?

< 2?

a/w ↑AST/ALT?

A

> 2 = liver dz esp if GGT 2x normal

< 2 = acute/chronic viral hep, NASH

a/w ↑AST/ALT = cholestatic dz