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Flashcards in Lesson 1 Deck (20)
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1
Q

Kind of controlled release

A

Delayed, pulsatile, extended, targeted, triggered

2
Q

good candidates for DDS

A

short half-lives, poor bioavailability, periodic dosing, narrow therapeutic index

3
Q

administration routes

A

parenteral, buccal, topical, ophthalmic, nasal, other (vaginal)

4
Q

components of nanopharmaceuticals

A

drug and carrier

5
Q

types of carrier

A

soluble macromolecule, micelles, nanoparticles, microparticles,lipoprotein,vesicles

6
Q

types of capillary

A

no pores, fenestrated, sinusoidal

7
Q

what to control in EPR effect

A

pressure, blood flow, reach the center of the tumor

8
Q

immune system

A

innate & specific

9
Q

opsonization

A

promotion of phagocytosis of antigens by macrophages and neutrophils, mediated by C3b

10
Q

Mononuclear phagocyte system

A

monocytes, kupffer cells, alveolar macrophages, histiocytes

11
Q

avoid MPS

A

coating with PEG

12
Q

kind of targeting

A

active (chemical, physical) passive

13
Q

benefits of vax

A

efficacious against diseases, mild reactions, risk smaller than natural disease, protection for oneself and the others

14
Q

antigen delivery steps

A

uptake, transport, processing, presenting

15
Q

crucial components of vax

A

particular form
immunostimulatory component
antigens

16
Q

particulate format function

A

depot
recognition signal
carrier of antigens

17
Q

modern delivery systems

A
virus-like particles
virosomes
iscoms
nano/microparticles
nanoemulsions
IRIV
18
Q

administrative routes

A

injection
transdermal
mucosal (nasal,oral,sublingual)

19
Q

potential of new vax

A

protective, therapeutic,less sides, easier

20
Q

risk of new vax

A

acute adverse effect
tolerance
unknow sustainability