Lecture 31 The Gut Microbiota in Health and Disease Flashcards Preview

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Flashcards in Lecture 31 The Gut Microbiota in Health and Disease Deck (8)
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1
Q

Firmicutes are reduced in what IBD

A

UC

2
Q

What features of IBD itself could affect the microbiota

A
  • Antibiotic use
  • Inflammation
  • Diarrhoea (affects transit time)
  • Host diet
  • Host genotype
3
Q

Define Probiotics

A

are live microorganisms which, when administered in adequate amounts confer a health benefit on the host- yoghurt added live bacteria (Lactobacillus casei)

4
Q

Define Prebiotics

A

a substrate that is selectively utilized by host microorganisms conferring a health benefit- spring onion, asparagus, artichokes (food for resident bacteria)

5
Q

Mechanism of Action for Probiotics

A
  1. Competition
  2. Bioconversions (diet)
  3. Production of vitamins
  4. Direct antagonism (pathogens)
  5. Competitive exclusion
  6. Barrier function
  7. Reduce inflammation
  8. Immune stimulation
6
Q

What type of bonds do probiotics contains

A

Beta 2-4 bonds- no enzymes in human body can digest it

7
Q

What is the ideal antibiotic

A

Bactericidal, narrow spectrum

8
Q

Example of bactericidal, narrow spectrum antibiotic

A

Polymyxin B

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