Lecture 23: Helicobacter Pylori Flashcards

1
Q

Recall the correlation between microbiota and disease

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2
Q

Pathogenicity is determined by:

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3
Q

Recall normal stomach morphology.

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4
Q

Recall what makes the stomach a hostile/sterile environment.

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5
Q

Recall some of the diseases in the GIT.

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6
Q

Describe chronic gastritis.

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7
Q

Describe gastrically adenocarcinoma

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8
Q

Describe gastric lymphoma.

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9
Q

Describe peptic ulcer.

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10
Q

Recall early treatment to gastric ulcers.

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11
Q

Briefly recall GIT microbial diversity.

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12
Q

Describe H. pylori.

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13
Q

Recall the factors behind H. pylori survival in the stomach.

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14
Q

Recall the relationship between H. pylori and GIT diseases.

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15
Q

Recall the other causes of peptic ulcer.

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16
Q

Recall epidemiology of H. pylori infection.

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17
Q

What factors affect H. pylori pathogenesis.

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18
Q

Recall the factor behind H. pylori genetic diversity.

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19
Q

Describe the factors behind H. pylori virulence.

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20
Q

Recall the host response to H. pylori infection.

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  • All H. pylori strains induce a marked immune response
    • Expression of pro-inflammatory cytokines and chemokines from gastric epithelial cells
    • Infiltration of immune cells
    • Production of ROS and RNS
  • Binding to gastric epithelium - BabA
  • Damage to gastric epithelium-CagAand VacA
  • Acute inflammatory response neutrophils and macrophages
  • Chronic inflammatory response involving the recruitment of T-cells (Th1-mediated response)
21
Q

Binding of H. pylori to epithelial cells initiates an __________________, which becomes _________ with the development of an adaptive immune response.

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Binding of H. pylori to epithelial cells initiates an acute inflammatory response, which becomes chronic with the development of an adaptive immune response.

22
Q

Recall H. pylori immune evasion.

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23
Q
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24
Q

Recall the specific immune response and pathogenesis and H. pylori.

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25
Q

Recall the consequences of severe gastritis.

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26
Q

Describe gastric and duodenal ulcers caused by H. pylori infection.

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27
Q

Recall the consequences of H. pylori infection.

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28
Q

Recall the treatment and prevention of H. pylori infection.

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