Lecture 14: Eye Development Flashcards Preview

Year 1: 05. Neuro Exam 1 > Lecture 14: Eye Development > Flashcards

Flashcards in Lecture 14: Eye Development Deck (44)
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1

When is the critical period for fetal eye development?

Weeks 4-8

2

What embryonic layers give rise to the eye?

Neuroectoderm

Surface ectoderm

Mesoderm/Neural Crest

3

What part of the brain does the eye originate from?

Diencephalon

4

What do the rims of the optic cup give rise to?

Iris and ciliary body

5

What muscles are the only muscles in the body to arise from neuroectoderm?

Dilator and Constrictor pupillae muscles

6

What embryonic layer gives rise to the stroma of the iris?

Neural Crest

7

What embryonic layer gives rise to the epithelium of the iris and the ciliary body?

Neuroectoderm

8

What embryonic layer gives rise to the smooth muscle cells of the ciliary body?

Mesoderm

9

What congenital disorders can predispose a patient to having separation of the pigmented and neural retina?

Down's syndrome

Marfan's syndrome

10

Redevelopment of the intraretinal space comes from separation of what layers?

Neural retina (inner layer) and pigmented retina (outer layer)

11

What is aniridia?

What can cause it?

 

Lack of iris tissue 

  • Defects in the Pax6 gene
  • Glaucoma, cataracts, other eye abnormalities 

12

Arrested development of what optic structure during the 8th week can result in aniridia?

Rim of optic cup

13

What embryonic layer gives rise to the lens of the eye?

Surface ectoderm

14

What structures of the lens are responsible for its transparent nature?

Primary lens fibers - columnar epithelium with dissociated nuclei

15

What optic structure do cataracts affect? 

Lens

16

Maternal rubella infection between 4-7 weeks gestation can have what effect on fetal eye development?

Congenital cataracts (vulnerable lens development)

Congenital glaucoma

Also can be caused by genetics, rubella virus, radiation, and enzyme deficiency 

17

A 3 week old patient presents with congenital cataracts. He is being breastfed. What is the most likely diagnosis?

Congenital Galactosemia 

-Accumulation of galactose from milk because of enzyme deficiency

18

What layer of meninges is the sclera continuous with?

Dura

19

What layers of meninges is the choroid continuous with?

Pia and arachnoid

20

What optic structure does the pupillary membrane arise from?

Sclera

21

When happens to the pupillary membrane?

Degenerates at Week 26

22

What secretes the aqueous humor in the posterior chamber?

Ciliary Epithelium 

23

What is the embryonic origin of primary vitreous humor?

Choroid (mesenchyme/NCC)

24

What makes the aqueous humor?

Ciliary Body

25

Abnormal neural crest migration to form the scleral venous sinus results in an inability to drain what ocular fluid?

Aqueous humor

26

Defects in what gene can cause congenital glaucoma?

CYP1B1

27

Elevated intraocular pressure can place patients at risk for what disorder?

Congenital Glaucoma

28

What is the embryonic origin of the extra-ocular muscles?

Prechordal mesenchyme

29

What embryonic artery gives rise to the Central Retinal Artery?

Proximal portion of the Hyaloid Artery

30

What does the Hyaloid A. supply during fetal eye development?

Inner layer of optic cup

Lens vesicle

Optic cup mesenchyme