Lecture 13: Microbiome Flashcards
Define microbiota, microbiome, pathobionts, commensalism.
Recall factors influencing the microbiota.
Recall the microbial diversity in GI tract.
Recall the function of the human gut microbiota.
Recall the role of microbiota in the immune system.
Recall how antibiotic-associated diarrhoea may arise.
Recall the interaction between the gut microbiome and CNS function.
- There is constant interaction between our microbiome and organs. Gut microbes influence the regulation of gene expression in the gut.
- Microbes in the gut send chemical signals which can influence memory, emotions and behaviour.
Recall the anatomy of the gut immune tissue.
Recall the changes in human microbiota over time.
- In utero environment has, until relatively recently, been considered sterile.
- However, DNA-based microbiota studies have detected bacterial species in the placentas of healthy mothers, in the amniotic fluid of preterm infants, and in meconium
- At parturition (birth), the mode of delivery influences postnatal microbial exposure
Recall the correlation between perturbed microbiota and immune-related disease
Recall the microbiome in health and disease.
______________________ modify pathogenesis of autoimmune diabetes by altering gut microbiota composition.
Recall the role of microbiota in type I Diabetes and Coeliac Disease.
Recall the hygiene hypothesis.
Recall the influence of microbiota on systemic inflammatory disease.
Define prebiotics, probiotics, synbiotics.
Recall how specific modification of the microbiome may benefit patients.
Recall formulating testable hypotheses on the role of microbiota in disease from sequencing data to generating novel therapeutics.
