Lecture 1 - Physiologic Disposition Flashcards Preview

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Flashcards in Lecture 1 - Physiologic Disposition Deck (78)
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1

Biotransformation is

Rx metabolism

2

Examples of physiologic dysfunction causing drug disposition

renal/liver, gastric motility (absorption)

3

Pharmacokinetics =

effect of BODY on drug (ADME)

4

Pharmacodynamics =

effect of DRUG on body

5

Central compartment connected to :

Therapeutic site of action
Tissue reservoir
Unwanted site of action
Kidney
Liver

6

In absorption/distribution, lipoid membranes b/w :

Rx origin "&" IM
Rx origin "&" GI
Central comp "&" peripheral comp
Central comp "&" excretion/reabsorption

7

Barriers to Central Compartment (Blood)

LIPID MEMBRANES
metabolic inactivation / chemical interactions

8

active transport forms

facilitated diffusion, drug transporters

9

passive transport forms

paracellular transport, diffusion, filtration, bulk transport, carrier-facilitated

10

Molecular size effect on Drug absorption

smaller the Rx = faster crossing membrane/absorption (pores and water channels)

11

Diffusion depends on

--LIPID SOLUBILITY
--Area/Thickness/Concentration Gradient

12

Diffusion : partition coefficient w/ absorption?

Big partition coefficient = faster reabsorption (more lipid soluble)

13

Ionized/Un-ionized goes across membrane by SIMPLE DIFFUSION?

ONLY UN-IONIZED molecule simple diffuses across membrane

14

Weak acid in Acidic pH becomes

less ionized

15

Weak base in Basic pH becomes

less ionized

16

pKa is

pH for 50/50 ionized/un-ionized

17

at steady state, weak bases go

from basic to acidic side
(un-ionized form crosses)

18

at steady state, weak acids go

from acidic to basic side
(un-ionized form crosses)

19

If pH is the same on both sides,

Rx total amount SAME on both sides

20

difference in pH causing ion movement towards opposite =

ion trapping, pH partitioning

21

IV pros

Rapid onset
Accurate level control
Direct

22

IV negs

Non-removable
High [ ] injections
Fluid overload

23

IM pros

better than SubQ (fast, less irritation, faster absorption w/ vasoconstrictor)

24

SubQ negs

pain, irritation/infxn, local necrosis
small volume only

25

Inhalation pros

surface area
perfusion
local + systemic
Need Equipment

26

Inhalation negs

Allergic Rxns
Route for party drugs "&" work toxins

27

how to enhance topical absorption

oily suspension, hydrated skin

28

which more permeable, dermis or epidermis

dermis (burns, denuded, abraded)

29

topical negs

allergic rxns

30

3 enteral routes

sublingual, rectal, oral