(Kress) [Review Article] ICU-Acquired Weakness and Recovery from Clinical Illness Flashcards Preview

Complexities in Acute Care Part 2 > (Kress) [Review Article] ICU-Acquired Weakness and Recovery from Clinical Illness > Flashcards

Flashcards in (Kress) [Review Article] ICU-Acquired Weakness and Recovery from Clinical Illness Deck (8)
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1

Critical Illness Polyneuropathy is characterised by

Primary axonal degeneration, without demyelination, that typically affects the motor nerves more than the sensory nerves

2

Critical Illness Polyneuropathy affects the ____ (particularly the _______) in a symmetrical pattern

limbs (particularly the lower extremities) in a symmetrical pattern

3

Both critical illness weaknesses are manifested by

limb and respiratory-muscle weakness and retained sensory function

4

It is suggested inactivation of ______ channels may contribute to critical illness weaknesses

inactivation of SODIUM channels

5

Can both conditions coexist (Critical Illness Polyneuropathy & Critical Ilness Myopath)

Yes -> Critical Illness Neuropathy

6

It is clear from studies that sepsis, persistent systematic inflammation, and multi organ failure are all

Important risk factors for ICU-Acquired Weakness

7

Key components in the pathophysiological process of Critical Illness Myopathy are

Oxidative Stress
Muscle Necrosis
Myosin Loss
Mitochondrial Dysfunction
Sodium Channel Inactivation

8

Key components in the pathophysiological process of Critical Illness Polyneuropathy are

- Motor nerves affected more than sensory nerves
- Nerve ischemia
- Nerve mitochondrial injury
- Sodium channel inactivation