What is the trade name of Isoproterenol?
Isuprel
What is the drug classification of Isoproterenol?
Synthetic catecholamine, selective for beta adrenergic receptors
What are the primary uses of Isoproterenol?
- chronotropic agent for heart transplant
- “chemical pacemaker” for heart block and bradydysrhythmias
- mild pulmonary vasodilating effects (reduce PulmVR)
What is the MOA of Isoproterenol?
Provides non-selective beta-adrenergic stimulation of Beta 1 > Beta 2
-also a pulmonary and systemic vasodilator
-activates beta adrenergic receptors via G protein coupled receptors.
Increases HR and contractility, with decreased SVR (Increased SBP; decreased DBP and MAP)
How is Isoproterenol metabolized and eliminated?
- rapidly metabolized in the liver by COMT (need infusion!)
- 40-50% eliminated unchanged in the kidneys
What is the typical dose for Isoproterenol?
1-5mcg/min (infusion 0.5-10mcg/min)
When should you avoid Isoproterenol?
CAD!
What is the e 1/2 life of Isoproterenol?
2.5-5 minutes
What is the onset and DOA of Isoproterenol?
Onset: immediate
DOA: 5-10 minutes
What are the side effects of Isoproterenol?
- tachycardia
- dysrhythmias
- decreased coronary BF 2dary to decreased DBP
- increased oxygen consumption d/t inotrope and chronotrope effects
- peripheral vasodilation and hypotension
What are the contraindications to Isoproterenol?
- Hypersensitivity
- Tachycardia caused by Dig toxicity
- CAD and angina
What are the drug interactions with Isoproterenol?
increased potential for arrhythmias with some general anesthetics and co-administration of other sympathomimetics