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Flashcards in Isoflurane Deck (12)
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1

Isoflurane boiling point

48.5 C

2

Isoflurane saturated vapor pressure

239.5

3

Isoflurane MAC

1.15 vol%

4

Isoflurane blood/gas coefficient

1.4

5

Isoflurane brain/blood coefficient

2.6

6

Isoflurane muscle/blood coefficient

4.0

7

Isoflurane fat/blood coefficient

45

8

Iso Pulmonary effects

Most decrease in tidal volume and increase in end tidal CO2 (equal to des). Causes respiratory depression. Less tachypnea than Halothane. MOST depression of ventilatory response to hypoxemia and hypercapnia. Similar hypoxic pulmonary vasoconstrictor response

9

Iso CV effects

Dose dependent decrease in BP from decreased SVR.
Mild myocardial depressant - worse with calcium channel blockers (CO does not increase even though filling pressures raise and SVR drops)..
Mild direct negative chronotropic effect (better than halothane)-- will actually result in increased HR from indirect activiation of sympathetic & autonomic nervous system and baroreceptor response to hypotension.
Minimal arrhythmogenicity
Coronary vasodilation & decreased coronary vascular resistance
Does not cause coronary steal

10

Iso burst suppression at what MAC?

1.5, electrical silence at 2 MAC

11

Iso liver:blood coefficient

1.8

12

Iso kidney:blood coefficient

1.2