Flashcards in Isoflurane Deck (42)
The lower the MAC necessary for anesthesia, the __ the potency and the __ the oil:gas partition coefficient.
Higher oil:gas partition coefficient
The constant for the Meyer-Overton equation is __ atmospheres
The oil:gas partition coefficient for Iso is __
Again, the higher the Oil-gas partition coefficient, the __ the lipid solubility AND potency
Iso causes immobility to painful stimuli by enhancing __ ion channels and reducing spinal neuron action potentials via __ and ___ receptor mediation.
Glycine and GABAa receptor mediation
The effects of general anesthetics are very __ , many different receptors in both brain and spinal cord
Receptors involved in the spinal cord include __, 5-hydroxytriptamine, __, NMDA, __, and AMPA
Glycine, 5-hydroxytriptamine, Na+, NMDA, K+, and AMPA
Receptors involved in the brain include Kainate, ___, ___, alpha-2, 5ht3, ___
Kainate, GABA, OPIOID, alpha-2, 5ht3, ACETYLCHOLINE
CFC's are colorless, odorless, nonflammable, noncorrosive gases or liquids. CFC stands for __
If iso were entirely fluorinated it would be a non-___
Racemic mixtures are __/__ mixes of stereoisomers
What is the BLOOD-gas partition coefficient of iso?
What is the vapor pressure of iso?
Is iso stable in moist soda lime and available generically?
Is it ok to use with a closed circuit?
Stable in soda lime means it doesn't make any bad compounds.
Does iso need a preservative? Does it produce compound A or carbon monoxide?
What is the metabolism rate of iso?
Iso is the only molecule with the __ atom
Sevo is the molecule with ___ fluorines
Des is the molecule with NO chlorines and __ fluorines
Does iso produce skeletal muscle relaxation?
MAC is completely ___ of the length of the anesthetic
Length of anesthesia DOES NOT increase or decrease MAC requirements.
What is the MAC for iso for age 36-49?
Dose of iso needed to produce apnea is around __ mac
Iso causes airway irritation around __ mac
Can you use an LMA with iso?
How much iso MAC for a deep extubation?
Iso causes peripheral vaso___ and __ body temps.
Decreases body temps
Does iso alter the hypoxia pulmonary vasoconstriction? HPV
Does iso predispose arrhythmias or protect against them?
Would your electrophysiologist want you to use iso?
Protects against them, anti arrhythmic
You EP would NOT want you to use iso because of that