Isoflurane Flashcards Preview

ANPH 500 - Pharmacology - McCarver > Isoflurane > Flashcards

Flashcards in Isoflurane Deck (42)
Loading flashcards...
0

The lower the MAC necessary for anesthesia, the __ the potency and the __ the oil:gas partition coefficient.

Greater potency
Higher oil:gas partition coefficient

1

The constant for the Meyer-Overton equation is __ atmospheres

1.8

2

The oil:gas partition coefficient for Iso is __

97

3

Again, the higher the Oil-gas partition coefficient, the __ the lipid solubility AND potency

Greater

4

Iso causes immobility to painful stimuli by enhancing __ ion channels and reducing spinal neuron action potentials via __ and ___ receptor mediation.

K+ channels

Glycine and GABAa receptor mediation

5

The effects of general anesthetics are very __ , many different receptors in both brain and spinal cord

Diffuse

6

Receptors involved in the spinal cord include __, 5-hydroxytriptamine, __, NMDA, __, and AMPA

Glycine, 5-hydroxytriptamine, Na+, NMDA, K+, and AMPA

7

Receptors involved in the brain include Kainate, ___, ___, alpha-2, 5ht3, ___

Kainate, GABA, OPIOID, alpha-2, 5ht3, ACETYLCHOLINE

8

CFC's are colorless, odorless, nonflammable, noncorrosive gases or liquids. CFC stands for __

Chlorine
Fluorine
Carbon

9

If iso were entirely fluorinated it would be a non-___

Immobilizer

10

Racemic mixtures are __/__ mixes of stereoisomers

50/50

11

What is the BLOOD-gas partition coefficient of iso?

1.46

12

What is the vapor pressure of iso?

238

13

Is iso stable in moist soda lime and available generically?
Is it ok to use with a closed circuit?

YES
Yes

Stable in soda lime means it doesn't make any bad compounds.

14

Does iso need a preservative? Does it produce compound A or carbon monoxide?

No
No
No

15

What is the metabolism rate of iso?

0.2%

16

Iso is the only molecule with the __ atom

Chlorine

17

Sevo is the molecule with ___ fluorines

Seven

18

Des is the molecule with NO chlorines and __ fluorines

Six

19

Does iso produce skeletal muscle relaxation?

Yes

20

MAC is completely ___ of the length of the anesthetic

Independent

Length of anesthesia DOES NOT increase or decrease MAC requirements.

21

What is the MAC for iso for age 36-49?

1.2

22

Dose of iso needed to produce apnea is around __ mac

2

23

Iso causes airway irritation around __ mac

1

24

Can you use an LMA with iso?

Yes

25

How much iso MAC for a deep extubation?

0.85 MAC

26

Iso causes peripheral vaso___ and __ body temps.

Vasodilation
Decreases body temps

27

Does iso alter the hypoxia pulmonary vasoconstriction? HPV

Yes

28

Does iso predispose arrhythmias or protect against them?

Would your electrophysiologist want you to use iso?

Protects against them, anti arrhythmic

You EP would NOT want you to use iso because of that

29

Iso abolishes baroreflexes around __ mac

1