Intro to Hemostasis & Primary Hemostasis Flashcards Preview

Med Lab Tech Fall 2016 > Intro to Hemostasis & Primary Hemostasis > Flashcards

Flashcards in Intro to Hemostasis & Primary Hemostasis Deck (38)
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1

Complex process by which the body spontaneously stops bleeding and maintains blood in the fluid state within the vascular compartment

Hemostasis

2

Major Functional Components ( interrelated) of Hemostasis

Blood vessels
Platelets
Coagulation proteins
Fibrinolysis
Serine protease inhibitors

3

What system of Hemostasis includes:

Increase vascular permeability
Contraction of smooth muscle
Dilation of small blood vessels
Induction of inflammation and pain
Release of prostaglandins

Kinin system

4

What system of Hemostasis includes:

Series of proteins, when activated participate in inflammation
React with fibrinolytic proteins and coagulation proteins

Complement system

5

Stage of hemostasis that includes:

Refers to the response to vascular injury that produces a platelet plug at the site of damage
Serves to limit bleeding immediately through the formation of a loose platelet plug by adhering to the endothelial wall at the site of injury

Primary Hemostasis

6

Stage of hemostasis that includes:

Involves the enzymatic activation of the coagulation proteins to produce fibrin from fibrinogen
Activated by the release of tissue factor from epithelial cells that are exposed to the circulation at the site of vascular injury

Secondary Hemostasis

7

Process of dissolving a clot
Involves the proteolytic digestion of fibrinogen and fibrin by the enzyme plasmin
Vascular healing and repair is promoted through the release of Platelet Derived Growth Factor (PDGF)

Fibrinolysis

8

These vessels Make up most of the microvasculature (smallest systems of blood vessels in a body)

Precapillary arterioles
Capillaries
Post capillary venules

9

Vessel layer that includes connective tissue and cell support


Tunica adventitia-

10

Vessel layer that includes Elastic tissue and smooth muscle, controls vasoconstriction and sometimes vasodilation

Tunica media-

11

Vessel layer that includes smooth non-wettable surface, facilitate migration of cells through the spaces as needed

Tunica Intima

12

__________ released causing blood vessels to undergo vasoconstriction

Vasoactive amines

Ex. Seritonin, epinephrine

13

Hormone to stimulate platelet production

Thrombopoietin

14

Platelet lifespan

Life span: 7 -10 days

15

Platelet normal range

Normal range: 150,000 to 400,000/µL

16

Platelets

_____ % circulate in the PB, _____% pooled in the spleen

70% circulate in the PB, 30% pooled in the spleen

17

Anucleated cytoplasmic fragments
2 to 4 µm in diameter

Originate from the BM megakaryocytes
Endomitosis ----->cytoplasmic fragments

Platelets

18

Platelet structure/zone

Serves as a stimulus receptor and transmitter.

Responsible for transport of intra and extra platelet substances

Contains a Glycocalyx ( amorphous exterior coat)

Contain:
Open Canalicular System (OCS)


Peripheral Zone

19

Platelet Structure/zone

Forms the cytoskeleton and allow platelet to maintain its shape

Microtubules encase the entire platelet, maintaining its discoid shape.

Include protein subunits, Tubulin

Microfilaments interwoven throughout the cytoplasm composed of actin and myosin

Sol-Gel Zone

20

Platelet Structure/Zone

Responsible for the metabolic activities of the platelet. (Storage and secretion)

Contains Alpha granules, Dense delta granules, and lysosomes

Organelle Zone

21

What Granule?

Used in storaging.

Most numerous
Contain: vWF, K+, Fibrinogen, Fibronectin, Platelet factor 4 and platelet factor 5

Alpha granules

22

What granule?

Contain substances that activate in response to form a platelet plug
Contain: ADP, ATP, serotonin, calcium, and phosphates

Dense (delta) granules (bodies)

23

Granule that Contain microbial enzymes, neutral proteases, and acid hydrolases

Lysosomes

24

refers to separate responses of platelet function that include adhesion, shape change, secretion, and aggregation

Respond in a graded fashion, depending on strength and duration of the stimuli

Platelet activation

25

Maintaining vessel wall integrity is the function of ______ cells, connective tissue of the _________, and ________.

Maintaining vessel wall integrity is the function of the endothelial cells, connective tissue of the subendothelium, and platelets

26

Normal intact endothelium is ___________.
It’s resistant to platelets, leukocytes, and coagulation proteins

nonthrombogenic

27

Platelet and endothelial cell interaction is modulated by the prostaglandin _____.

Platelet and endothelial cell interaction is modulated by the prostaglandin PGI2

28

[Maintenance of Vascular Integrity]

This Promotes endothelial cell and smooth muscle cell migration
Maintains vascular integrity and thromboresistant properties
Found in alpha granules of platelet

Platelet Derived Growth Factor (PDGF)

29


Reversible process
Requires three critical components:
vWF- a plasma protein that links the platlet to subendothelial binding sites
Platelet membrane receptor, GPIb
Collagen fibers
Adherent platelets undergo a shape change

Adhesion

30

Platelet-to-platelet interaction
Begins 10 to 20 seconds after vascular injury and platelet adhesion
Initially caused by ADP from injured tissue
Energy dependent process requiring ATP

Aggregation