Flashcards in Intro to Hematologic Malignancies Deck (45)
_______ express TdT
A malignancy of hematopoietic cells where the main manifestation is in the blood and marrow
A malignancy of hematopoietic cells, derived from lymphocytes or precursors, that presents primarily as a solid mass
A malignancy of hematopoietic cells, derived from myeloid cells or precursor, presenting primarily as a solid mass
Extramedullary Myeloid Tumor
ALL is a worse disease in ______ (demographic).
ALL is more common in _______ (demographic).
AML is more common in ______ (demographic).
Older adults (Avg. age: 65)
B-lymphoblasts often express ________.
CD19, CD22, and CD79a
CD117 is often seen in ______.
CD14 is often seen in ______.
CD19 is often seen in __-lymphoblasts.
CD1a is often seen in _______.
CD2 is often seen in __-lymphoblasts.
CD20 is often seen in _____.
Mature B cells
CD22 is often seen in __-lymphoblasts.
CD3 is often seen in __-lymphblasts.
CD34 is often seen in ______.
CD4 and/or CD 8 are often seen in __-lymphoblasts
CD41 is often seen in _____
CD61 is often seen in _______.
CD64 is often seen in ______.
CD7 is often seen in __-lymphoblasts.
CD79a is often seen in __-lymphoblasts.
CD99 is often seen in _______.
Chemotherapy treatment that increases risk of acute leukemia
DNA-alkylating agents and Topoisomerase II inhibitors
Effects of leukemia that are direct but rare (3)
Thrombotic events (leukostasis), DIC, Infiltration of Tissues (skin, gums, lymph nodes, etc.)
Epstein Barr Virus has an oncogenic role in the following lymphomas: ______
Burkitt, Hodgkin, B-Cell Non-Hodgkin
Genetic Syndromes associated with increased risk of leukemia
Down Syndrome, Blood Syndrome, Fanconi anemia, ataxia-telangiectasia
Group of conditions where a clonal population derived from a neoplastic hematopoietic stem cell takes over the marrow, such that the marrow is not capable of making normal blood cells in one or more lineages