Intro to Hematologic Malignancies Flashcards Preview

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Flashcards in Intro to Hematologic Malignancies Deck (45)
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1

_______ express TdT

Lymphoblasts

2

A malignancy of hematopoietic cells where the main manifestation is in the blood and marrow

Leukemia

3

A malignancy of hematopoietic cells, derived from lymphocytes or precursors, that presents primarily as a solid mass

Lymphoma

4

A malignancy of hematopoietic cells, derived from myeloid cells or precursor, presenting primarily as a solid mass

Extramedullary Myeloid Tumor

5

ALL is a worse disease in ______ (demographic).

adults

6

ALL is more common in _______ (demographic).

children

7

AML is more common in ______ (demographic).

Older adults (Avg. age: 65)

8

B-lymphoblasts often express ________.

CD19, CD22, and CD79a

9

CD117 is often seen in ______.

Myeloid Cells

10

CD14 is often seen in ______.

Monocytes

11

CD19 is often seen in __-lymphoblasts.

B

12

CD1a is often seen in _______.

T-lymphoblasts

13

CD2 is often seen in __-lymphoblasts.

T

14

CD20 is often seen in _____.

Mature B cells

15

CD22 is often seen in __-lymphoblasts.

B

16

CD3 is often seen in __-lymphblasts.

T

17

CD34 is often seen in ______.

immature cells

18

CD4 and/or CD 8 are often seen in __-lymphoblasts

T

19

CD41 is often seen in _____

Megakaryoblasts

20

CD61 is often seen in _______.

Megakaryoblasts

21

CD64 is often seen in ______.

Monocytes

22

CD7 is often seen in __-lymphoblasts.

T

23

CD79a is often seen in __-lymphoblasts.

B

24

CD99 is often seen in _______.

T-lymphoblasts

25

Chemotherapy treatment that increases risk of acute leukemia

DNA-alkylating agents and Topoisomerase II inhibitors

26

Effects of leukemia that are direct but rare (3)

Thrombotic events (leukostasis), DIC, Infiltration of Tissues (skin, gums, lymph nodes, etc.)

27

Epstein Barr Virus has an oncogenic role in the following lymphomas: ______

Burkitt, Hodgkin, B-Cell Non-Hodgkin

28

Genetic Syndromes associated with increased risk of leukemia

Down Syndrome, Blood Syndrome, Fanconi anemia, ataxia-telangiectasia

29

Group of conditions where a clonal population derived from a neoplastic hematopoietic stem cell takes over the marrow, such that the marrow is not capable of making normal blood cells in one or more lineages

Myelodysplastic Syndrome

30

Immature cells often express ____.

CD34