Integumentary Pharmacology Flashcards Preview

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Flashcards in Integumentary Pharmacology Deck (15)
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1
Q

Silver sulfadiazine (silvadene) and mafenide acetate (sulfamylon)

A

Sulfonamides that disrupt the synthesis of folic acid necessary for DNA, RNA and protein synthesis. This action makes sulfonamides broad spectrium antimicrobials

2
Q

Indication for silver sulfadiazine (silvadene) and mafenide acetate (sulfamylon)

A

Burns and open wound care

3
Q

Side effects silver sulfadiazine (silvadene) and nafenide acetate (sulfamylon)

A

Pain and acidosis.

4
Q

Prior to performing wound care, __ should be administered to decrease pain

A

Analgesics

5
Q

MOA silver sulfadiazine and mafenide acetate

A

Topical antimicrobial

Decreases bacteria such as pseudomonas aeruginosa

6
Q

Silver sulfadiazine

A

Releases free silver to suppress bacterial colonization and decrease antimicrobial counts

7
Q

Mafenide acetate

A

Acts as a sulfonamide and disrupts bacterial DNA synthesis by interrupting folic acid synthesis

8
Q

Since mammalian cells use preformed folic acid obtained by diet, the drug does not harm mammalian DNA and protein synthesis

A

Ok

9
Q

Indication for silver sulfadiazine and mafenide acetate

A

Burns open wound care

10
Q

Burns silver sulf and mafenide acetate

A

Decrease bacterial colonization in patients with second and third degree burns
Help prevent the progression of second degree wounds into third degree

11
Q

Silver sulf burns

A

Softens Escher and helps with the removal of dead tissue fo grafting

12
Q

Side effects silver s and mafenide a

A

Ss no significant side effects

Mafenide-serious side effects

13
Q

What open would can we use ss and ma on

A

Herpes blisters, burns

14
Q

Mafenide side effects

A

Pain and acidosis (metabolized into a chemical that decreases the kidneys ability to excrete acids)

15
Q

Why give analgesic prior to wound care with mafenide

A

Causes pain