Innate Immunity Receptors Flashcards Preview

Basic Immunology- Module 1 > Innate Immunity Receptors > Flashcards

Flashcards in Innate Immunity Receptors Deck (91)
Loading flashcards...
1

What are DAMPs?

indicator molecules of cellular infection, damage, stress or transformation

2

What cytokine are macrophages dependent on for self-renewal?

IL34

3

What is the function of patrolling monocytes?

survey for injury to the endothelium by rolling along the rndothelium

4

What do classical monocytes express on their surface?

CD14

5

What are the 2 types of dendritic cell?

conventional/classical and plasmocytoid

6

What is the main function of plasmocytoid dendritic cells?

production of type 1 interferons

7

What is the function of dectin-1 receptor?

recognises beta-1,3-linked glucans foudn on fungal cell walls

8

what cells express dectin-1?

macrophages; neutrophils and dendritic cells

9

What type of receptor is the mannose receptor?

C-type lectin

10

What cells are scavenger receptors found on?

macrophages

11

What is the function of scavenger receptors?

recognise various anionic polymers and cetylated low-density lipoproteins

12

what is the function of class A scavenger receptors?

bind various bacterial cell wall components and help internalise bacteria

13

Waht is the function of class B scavenger receptors?

bind HDL and internalise lipids

14

What pathogens are Toll-like receptors critical for defense against?

gram-positive bacteria and fungi

15

What is the function of Toll signalling?

induces expressiong of several host-defence mechsnism

16

What PAMP is recognised in a gram positive bacterial cell wall?

lipoteichoic acid

17

Waht PAMP is recognised in a gram negative bacterial cell wall?

lipopolysaccharide

18

What toll-like receptor recognises double stranded RNA (viruses)?

TLR3

19

What does TLR4 recognise?

LPS and LTA

20

What toll-like receptor recognises flagellin?

TLR5

21

What toll-like receptor is paired with TLR6?

TLR2

22

What TLR is paired with TLR1?

TLR2

23

What toll like receptors recognise single stranded RNA (viruses)

TLR7 and TLR-8

24

What TLR recognises DNA with unmethylated CpG?

TLR9

25

What organisms are found to have DNA with unmethylated CpG?

bacteria and herpesviruses

26

Are TLRs sensors for microbes in the intra/extraceullar environment?

extracellulae

27

What is the function of TLRs found on endosomes?

detect pathogens that have been taken up by phagocytosis, receptor mediated endocytosis or macropinocytosis

28

What is the extracellular componenet of a TLR composed of?

leuceine-rich repeats

29

What happens when a toll-like receptor is activated?

formation of a dimer or induces conformational changes in a preformed TLR dimer

30

What is the foudn on the cytoplasmic tail of all toll-like receptors?

toll-IL-1 receptor domain