Flashcards in Innate Immunity Receptors Deck (91)
What are DAMPs?
indicator molecules of cellular infection, damage, stress or transformation
What cytokine are macrophages dependent on for self-renewal?
What is the function of patrolling monocytes?
survey for injury to the endothelium by rolling along the rndothelium
What do classical monocytes express on their surface?
What are the 2 types of dendritic cell?
conventional/classical and plasmocytoid
What is the main function of plasmocytoid dendritic cells?
production of type 1 interferons
What is the function of dectin-1 receptor?
recognises beta-1,3-linked glucans foudn on fungal cell walls
what cells express dectin-1?
macrophages; neutrophils and dendritic cells
What type of receptor is the mannose receptor?
What cells are scavenger receptors found on?
What is the function of scavenger receptors?
recognise various anionic polymers and cetylated low-density lipoproteins
what is the function of class A scavenger receptors?
bind various bacterial cell wall components and help internalise bacteria
Waht is the function of class B scavenger receptors?
bind HDL and internalise lipids
What pathogens are Toll-like receptors critical for defense against?
gram-positive bacteria and fungi
What is the function of Toll signalling?
induces expressiong of several host-defence mechsnism
What PAMP is recognised in a gram positive bacterial cell wall?
Waht PAMP is recognised in a gram negative bacterial cell wall?
What toll-like receptor recognises double stranded RNA (viruses)?
What does TLR4 recognise?
LPS and LTA
What toll-like receptor recognises flagellin?
What toll-like receptor is paired with TLR6?
What TLR is paired with TLR1?
What toll like receptors recognise single stranded RNA (viruses)
TLR7 and TLR-8
What TLR recognises DNA with unmethylated CpG?
What organisms are found to have DNA with unmethylated CpG?
bacteria and herpesviruses
Are TLRs sensors for microbes in the intra/extraceullar environment?
What is the function of TLRs found on endosomes?
detect pathogens that have been taken up by phagocytosis, receptor mediated endocytosis or macropinocytosis
What is the extracellular componenet of a TLR composed of?
What happens when a toll-like receptor is activated?
formation of a dimer or induces conformational changes in a preformed TLR dimer