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What are fungi? What are they divided into?

Eukaryotic organisms so they have a true nuclei
Divided into yeasts and moulds

1

Fungi are carbon heterotrophs. What does this mean?

They require preformed organism compounds as carbon sources

2

What are dermatophytes?

Moulds
Keratinophilic: associated with infections of the skin nails and hair and get spread through direct contact.
Common symptoms include itching burning and pain

3

What is common in the name of dermatophytes??

Tinea
Eg tinea corporis
Tinea cruris

4

What is tinea corporis?

Ringworm of the skin

5

What is tinea cruris?

Ringworm of the groin

6

What is tinea capitis?

Ringworm of the scalp
Cap= scalp!

7

Dermatophytes are usually diagnosed visually or by sending nail clippings off for analysis.
What does ring worm look like?

Raised around the edges with a clear area in middle

8

What is first line treatment for tinea corporis and tinea cruris?

Topical imidazole
Eg clotrimazole, ketoconazole
Should treat with creams for a further two weeks to ensure it goes away

9

If topical treatment fails, or if someone's immuno compromised or the infection is particularly wide spread, what can we use to treat tinea corporis and cruris?

Terbinafine ORALLY
250mg a day for 4 weeks

10

What do we use to treat tinea Capitis? (Ringworm of scalp)

Usually oral treatment is required such as Terbanifine or griseofulvin, PLUS:
Ketoconazole/ selenium sulphide shampoos or terbanafine creams twice weekly

11

What organisms is griseofulvin effective against?
What about terbinafine?

Griseofulvin effective against Trichophyton tonsurans, microsporum spp.
Terbinafine effective against Trichophyton tonsurans

12

Griseofulvin is only effective against dermatophytes. Why are long courses needed? Who should avoid it?

Long course as it does not persist in keratinous tissue after the end of therapy
Shouldn't be taken by people with severe liver disease, and systemic lupus erythematosus
Should be avoided in breast feeding
Avoid in pregnancy and for one month after stopping treatment

13

What are the main side effects of griseofulvin?

GI side effects
Cognitive effects
Hypersensitivity reactions

14

Griseofulvin has many interactions. What are these?

Enhances effects of alcohol
Decreases efficacy of oral contraceptives and coumarins

Needs to be taken with or after fatty foods!

15

What is used first line to treat athletes foot?

Imidazole cream
For 2-4 weeks or
Terbinafine cream for 1 week
Undecenoates for 2-4 weeks

16

If topical treatment fails for severe athletes foot, what three oral tablets could be taken? (Just say names)

Terbinafine
Itraconazole
Griseofulvin

17

Terbinafine can be taken orally or topically. It concentrates in keratinous tissue. When should it be avoided? What are the side effects?

Avoid In pregnancy and liver disease.
Side effects:
GI disturbance
Hepatotoxicity with prolonged therapy
Serious skin reactions

18

What species can we commonly find infecting our nails?

Trichophyton rubrum
Epidermiohyton floccosum
Trichophyton mentagrophytes

19

Onychomycosis means nails. What's the most common type of nail infection?

DLSO starts at the top of the nail works down to nail bed

20

What's a good treatment for fungal nails?

Itraconazole pulse therapy
Itraconazole stays in keratin in nails for longer

Can also use itraconazole 200mg daily for 3 months
Could also use terbinafine for 6 weeks to 3 months
Note this is all SYSTEMIC management, taken orally

21

We can also use topical treatment for nail infections eg Ticonazole, Amorolfine. When is this appropriate to use?

Topical treatment will only work in mild distal disease in up to 2 nails. White superficial and early DLSO.
Localised distal nail may respond to Ticonazole or amorolfine

22

What is pityriasis versicolor?

Colonisation of the stratum corneam (in skin)
Caused by malassezia furfur
Starts at the neck and shoulders, multiple dark patches
Starts around puberty

23

What can we treat pityriasis versicolor with?

Ketoconazole shampoo
Clotrimazole or ketoconazole creams
Terbinafine cream

If these fail
Oral treatment:
Itraconazole
Fluconazole
Relapse is COMMON

24

Why is oral ketoconazole not really used anymore?

Can cause serious and rapid hepatotoxicity
Should only be given under specialist advice
Monitor liver function before and 2-4 weeks after treatment then monthly.

25

What topical therapy can we give for oropharyngeal candida?

First line: Imidazole antifungals eg miconzaole oral gel for 7 days
Second line: Polyene antifungals such as nystatin suspension 7 days

26

What oral therapies can be given for oropharyngeal candida?

Fluconazole
50mg daily for 7-14 days


Give it for 14 days if atrophic candidiasis associated with dentures

27

What fungal organism accounts for 90% of vaginal candidiasis?

Candida albicans

28

What topical treatments are effective for uncomplicated Vuvovaginal candidiasis?

Clotrimazole,
Econazole
Miconzaole

29

What oral treatments do we give for vaginal candidiasis?

Fluconazole (150mg single dose)
Itraconazole (200mg twice daily for one day)

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