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Flashcards in Induction Drugs Deck (2)
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1
Q

Drugs that are derived from:
Barbaturic acid

A

Barbituates

2
Q

Barbituates Preparation

what is it incompatible with?

A

Barbiturate Preparation

  • Sodium salts in alkaline solution
    • pH of 2.5% sodium thiopental = 10.5
  • Barbs are weak acids
  • pK for STP is 7.6
  • > or < 50 non-ionized in plasma?
  • Incompatible in solution with opioids, catecholamines and NMBAs –>Precipitates form… can be a huge

problem
¢ Available as racemic mixtures