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Flashcards in Immunophysiology Deck (163)
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151

Antigen-dependent phase of cellular aquired immunity

If Ti cell carries CD4 antigen:

  • Cell can recognise an antigen on an APC with an MHC-II antigen
  • Link between APC and Ti-cell = Primary stimulation
  • Ti cell activation → blastic transformation
  • T helper cell produced

152

Ti-cells with a CD8 antigen...

Recognises antigens expressed beside MHC-1 antigen

Tumour and virus antigens

Leads to Cytotoxic T-cells being produced

 

153

Cytotoxic T-cell

Immediately kills cells with tumor and virus antigens

154

Give the stages of T-lymphocyte maturation in the thymus

  1. T-lymphocyte receptors appear
  2. Immature lymphocytes can bind to MHC structures
  3. Positive selection: Only lymphocytes that can bind survive
  4. Negative selection: Lymphocytes which recognise both MHC and Self-Ag must die.

155

CD8+ cytotoxic T cells 

  • Kill virally infected cells
  • Kill tumor cells
  • Kill cells with cytosolic bacteria

156

CD4+ T cells (TH)

  • Cytokine production
  • TH1: Activates macrophages
  • TH2: Activates B cells → Antibody production

157

Latency

158

Log-phase

159

Plateau

160

Decrease

161

Primary response

162

Secondary response

163

What is shown in the diagram

The interactions vetween the nervous, endocrine and immune systems