Immunopharmacology II

Question 1

what are the classes of immunosuppressive antibodies

Answer 1

I-MOP

Immunostimulants
Monoclonal antibodies
Other Biological Agents
Polyclonal Antibodies

Question 2

what are the polyclonal antibodies

Answer 2

Antithymocite globulin

Rho(D) immunoglobulin

Question 3

uses of antithymocite globulin (ATG) anti lymphocyte globulin (ALG)

Answer 3

used before stem cell transplantation to prevent graft vs. host reaction

Question 4

uses of Rho (D) immunoglobulin

Answer 4

given to Rho(D) negative women after exposure to antigen (birth of Rho(D) + baby) to prevent erythroblastosis fetalis/hemolytic anemia of newborn in future pregnancies

Question 5

what are the monoclonal antibodies

Answer 5

AEIOB

Adalimumab
Etanercept
Infliximab
Omalizumab
Basiliximab

Question 6

of all the monoclonal antibodies, which are the anti TNFα and what are they at an increased risk of developing

Answer 6

Adalimumab, Etanercept, Infliximab

increased risk of infection or reactivating TB, hep B, and systemic fungi

Question 7

what are all the anti TNFα used to treat (name them)

Answer 7

Adalimumab, Etanercept, Infliximab

RA
Ankylosing Spondylitis
Psoriatic arthritis
IBD

Question 8

adverse effects of anti TNFα (name them)

Answer 8

Adalimumab, Etanercept, Infliximab

cytopenias
serious infections like bacterial sepsis and TB
increased risk of malignancies

Question 9

mechanism of Omalizumab

Answer 9

binds to IgE –> prevents it from binding to mast cells and basophils –> prevents release of inflamm mediators after allergen exposure

Question 10

mechanism of Basiliximab

Answer 10

chimeric human mouse IgG that binds to IL-2 receptor on activated lymphocytes

aka IL-2 receptor antagonist

Question 11

what are the OTHER biological agents and mechanism

Answer 11

RAA

Rituximab - binds to CD20 on B cells causing depletion of circulating B cells

Abatacept - fusion protein that interferes with T cell activation

Anakinra - IL-1 receptor antagonist

Question 12

what are the immunostimulants

Answer 12

ABI

Aldesleukin
BCG
Inteferons

Question 13

what do immunostimulants do/ treat

Answer 13

stimulate immune response including tx for immune deficiency diseases, chronic infectious diseases, cancer

Question 14

what is aldesleukin

Answer 14

a recombinant IL-2 that promotes production of cytotoxic T lymphocytes and activates NK cells