Immunomodulators, Immunohematology, Immunodiagnosis, AIDS, and Tumor Immunology Flashcards Preview

Blood and Lymph > Immunomodulators, Immunohematology, Immunodiagnosis, AIDS, and Tumor Immunology > Flashcards

Flashcards in Immunomodulators, Immunohematology, Immunodiagnosis, AIDS, and Tumor Immunology Deck (85)
Loading flashcards...
1

_____ have receptors for the Fc of IgG (FcγR), such that they interact with antibody on the targeted tumor cells in ADCC

NK cells

2

______ (anti-____) and ________ (anti-____) inhibit downregulators of CTL activity

Nivolumab (PD-1), Ipilimimab (CTLA-4)

3

______ phenotype individuals do not have H antigen on the core sugar chain

Bombay

4

_______ formation: virus makes _______ that inserts into the host cell membrane, which enables fusion of nearby uninfected CD4 cells

Syncytia; gp120/gp41

5

________ occurs in Rh(D)+ fetuses that are born to Rh(D)- mothers that have made anti-Rh(D) antibodies

Hemolytic Disease of the Newborn (HDN)

6

__% of individuals in the US living with AIDS have not been diagnosed

16

7

2/3 of Elite Controllers have the _____ allele.

HLA-B27

8

A subclass of TAAs that can be recognized by the immune system and used to clear the tumor

Tumor Rejection Antigens

9

Activated ______ allows virus to bind a co-receptor: _______ (chemokine receptors)

gp120; CCR5 or CXCR4

10

Activated TAA-specific ____ kill tumor cells by inducing apoptosis via perforin or Fas-mediated pathways

CTLs

11

Advantages of Passive Agglutination over Simple Precipitation

Determination of antibody titer, More sensitive (larger effective size of antigen)

12

Antibodies against TNF-alpha

infliximab, adalimumab, certolizumab pegol

13

Antibodies to one antigen that bind to another (cross-reactive antibodies)

Heterophiles

14

Antibody Source: -omab

Murine

15

Antibody Source: -umab

Fully Human

16

Antibody Source: -ximab

Chimeric (Mouse variable, Human constant)

17

Antibody Source: -zumab

Humanized (Mouse CDRs)

18

Antibody Technique: coupled antibodies that are anti-CD19 (on CD19+ B cell lymphoma cells) and anti-CD3

Bispecific T cell engager (BiTE)

19

Antibody Technique: high affinity antibody CDRs coupled to a transmembrane domain that has a T-cell intracellular signaling molecule

Chimeric Antigen Receptor (CAR)

20

Antigen used in monitoring therapy of colon cancer but not in diagnostic screening

Carcinoembryonic Antigen (CEA)

21

Antigens made in normal fetal tissue, not normally made in adults but may be re-expressed in a tumor

Oncofetal antigens

22

Antigens that are expressed uniquely on the malignant clone

Clonal antigens

23

Antigens that are overexpressed or abnormally expressed by tumor cells

Tumor Associated Antigens

24

Cell type: down-regulated if the target cell expresses Class I MHC

NK cells

25

Cell type: recognize stress-related markers on tumor cells, using a small number of innate receptors

NK cells

26

Cell type: recognize TAA presented by MHC Class I

CTLs

27

Cell type: recognize tumor antigens, make lymphokines, and attract M1 macrophages

Th1

28

Cross-reactive antibodies with phospholipids in beef heart enable diagnostic screening for ______.

Treponema Pallidum

29

CTLs have two checkpoint inhibitor surface receptors (_______) which can be engaged to downregulation cytotoxic activity

CTLA-4 and PD-1

30

Diagnostic Technique: add fluoroscein-labeled goat anti-human IgG to patient serum/sample, observe for fluorescence

Direct Immunofluorescence