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CMBM E3 CB > Immunology > Flashcards

Flashcards in Immunology Deck (5)
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1
Q

What is primary lymphoid tissue?

A

Where stem cells differentiate into either T cells (thymus) or B cells (bone marrow).

2
Q

What is secondary lymphoid tissue?

A

Where mature T/B cells go to encounter antigens.

3
Q

Where is secondary lymphoid tissue in the body?

A

Lymph nodes
Spleen
MALT (mucosal-associated lymphoid tissue) and other locations in the body with excess lymphatic accumulations

4
Q

What three activities take place in the thymus?

A
  1. Differentiation of thymocytes into T cells: early thymocytes express antigen receptors
  2. Self/non-self discrimination
  3. Elimination of self-reacting thymocytes
5
Q

What is involved in differentiation of thymocytes?

A
  1. Cell-to-cell contact with cortical epithelial cells and dendritic cells
  2. Thymic hormones
  3. Cytokines