Immunogenetics and Transplantation Flashcards Preview

MS1 - Blood & Lymph > Immunogenetics and Transplantation > Flashcards

Flashcards in Immunogenetics and Transplantation Deck (10)
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1
Q

The most important loci within the HLA loci are ________.

A

HLA-A, HLA-B (both of which are MHC II), and HLA-DR (MHC I)

2
Q

The MHC set that you inherit from one parent is called a ______.

A

haplotype

3
Q

In an MLR reaction, the _______ cells are treated to prevent division.

A

donor’s (because we just want to see if the recipients T cells will divide in response to the donor’s MHC)

4
Q

Because of H-Y, _____ grafts will be rejected by ________.

A

male; females

5
Q

Allografts are ___________.

A

transplants between non-identical members of the same species.

6
Q

Xenografts are _____________.

A

transplants between members of different species

7
Q

Isografts are _________.

A

grafts between identical twins

8
Q

Autografts are __________.

A

transplants within the same individual

9
Q

CTLs require both _____ and ____ to become activated.

A

IL-2; foreign cells/infected cells

10
Q

Why is a good class II MHC activation important in a foreign-body situation?

A

Because class II activation (in Th1 cells) releases IL-2, an attractant for CTLs, and IFN-gamma, an attractant for macrophages

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