Immuno Meds and Treatments Flashcards Preview

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Flashcards in Immuno Meds and Treatments Deck (15)
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1
Q

NRTIs

A
Abacavir - hypersensitivity rxns
Emtricitabine
Lamivudine
Zidovudine - BM suppression (anemia, neutropenia)
Tenofovir - kidney injury, bone loss

MOA: inhibit production of DNA from viral RNA, preventing incorporation of viral DNA into host genome

S/E:
Lactic acidosis
Lipodystrophy

2
Q

NNRTIs

A

Efavirenz - teratogenic, neuropsych - nightmares, depression
Etravirine
Rilpivirine

MOA: inhibit reverse transcriptase by blocking the transcription of DNA from viral RNA

S/E: rash

3
Q

Protease inhibitors

A
Atazanavir - hyperbilirubinemia
Darunavir
Fosamprenavir
Lopinavir
Ritonavir - booster, inhibits CYP450

MOA: interfere with viral replication and cause production of nonfunctional viruses

S/E:
hyperglycemia
hypertriglyceridemia
GI tox - N/V/D

4
Q

Integrase inhibitors

A

Elvitegravir
Dolutegravir
Raltegravir

MOA: block integration of the viral genome into host genome

well tolerated

5
Q

CCR5 antagonists

A

Maraviroc

MOA: block CCR5 coreceptor binding, preventing the entry of virus into the cell

6
Q

Fusion inhibitors

A

Enfuvirtide

MOA: bind to gp41 and prevent the fusion of HIV viruses to CD4 cells

7
Q

Azothioprine

A

purine synthesis inhibitor - prevent organ rejection

S/E:
Bone marrow suppression
Leukopenia

Do not give with allopurinol - metabolized by xanthine oxidase

8
Q

Tacrolimus

A

IL-2 inhibitor - prevent organ rejection

S/E:
nephrotoxicity when given systemically
Hepatotoxicity

9
Q

S/E of corticosteroids

A

cushingoid features
osteoporosis
diabetes

10
Q

Muromonab

A

Antibody immunosuppressant - prevent organ rejection

S/E leukopenia

11
Q

Rapamycin

A

IL-2 inhibitor - prevent organ rejection

S/E:
thrombocytopenia
Hyperlipidemia

Risk pneumonitis, metabolic syndrome

12
Q

Mycophenolate

A

Purine synthesis inhibitor - prevent organ rejection
used in lupus nephritis

S/E: leukopenia

Risk: lymphoma

Teratogen - ear, face, 1st trimester miscarriage

13
Q

Anti-thrombocyte globulin

A

Antibody immunosuppressant - prevent organ rejection

S/E: depletes T cell population

14
Q

Hydroxychloroquine

A

prevent organ rejection
Used in lupus and RA

S/E: macular degeneration
GI effects

15
Q

Thalidomide

A

prevent organ rejection

Teratogen - flipper limb deformity