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Flashcards in Identifying disease Deck (14)
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1
Q

how can a case studies be used to identify cause for a disease

A

if multiple case studies report similar findings

2
Q

how can a case-control studies be used to identify cause for a disease

A

if certain exposures are significantly more common in the cases group then it can reassumed that that exposure is the potential cause of the disease

3
Q

how can a cohort studies be used to identify cause for a disease

A

exposures which are more common in those who develop the disease could be identified as the potential cause of a disease

4
Q

how can a RCT study be used to identify cause for a disease

A

e. g. if the new treatment targets a specific protein (e.g. TK in CML) and the drug caused the slowing in progression of the disease- then the protein could be concluded as the cause of CML
- -> due to RCTs reducing the influence of confounding

5
Q

Kochs postulates

A

1) disease causing agent must be present in all of those with the disease
2) disease causing agent must be purified and cultured
3) disease causing agent must cause disease when given to healthy
4) disease causing agent must be preisolated and confirmed to be the same agent

6
Q

viral DNA will never be longer than

A

300bp

7
Q

how can observational studies generate hypotheses

A

by recording exposures which seem to be more prevalent in certain diseases
e.g. observing that most individuals with lung cancer smoke/ have smoked

8
Q

how can these hypotheses be tested

A

using trials

9
Q

why would you use a cohort over a case-control

A

the best information about the causation of disease, because you follow persons from exposure to the occurrence of the disease.

10
Q

cohort studies work well for

A

rare exposures

11
Q

case-controls are sometimes better than cohorts since

A
  • no follow up period- therefore quick and cheap

- good for rare diseases, but not rarer causes

12
Q

case-controls are more prone to

A

bias than cohort

  • cant match groups
  • no randomisation
13
Q

often use observational studies

A

to justify interventional studies

14
Q

generally accepted that observational studies can..

A

distinguish associations between events but cannot conclude that one event causes another