I - Cell Injury, Cell Death and Adaptations Flashcards Preview

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Flashcards in I - Cell Injury, Cell Death and Adaptations Deck (105)
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61

Most common exogenous pigment?

Carbon(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.26

62

"Wear and Tear pigment"?

Lipofuschin(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.26

63

Pigment produced by tyrosinase-catalyzed oxidation of tyrosine to dihydroxyphenylalanine.

Melanin(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.26

64

Hemoglobin-derived granular pigment that is golden-yellow to brown in color. Accumulates in excess of iron.

Hemosiderin(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.26

65

Histochemical reaction used to identify hemosiderin.

Prussian blue test(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.26

66

Abnormal calcium deposition occuring in the absence of calcium metabolic derangements.

Dystrophic calcification.(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.26

67

Calcium deposition in normal tissues occuring in the presence of hypercalcemia.

Metastatic calcification (TOPNOTCH)Robbins Basic Pathology, 8th ed. p.26

68

Grossly seen as fine white granules or clumps, often felt as gritty deposits. Histologically, intra/extracellular basophilic deposits.

Calcium salts(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.27

69

A result of a progressive decline in the proliferative capacity and lifespan of cells.

Cellular aging(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.29

70

Appears as round or oval masses with intensely eosinophilic cytoplasm, nuclei with various stages of chromatin condensation and aggregation, karyorrhexis.

Apoptotic cell(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.20

71

Membrane bound vesicles of cytosol and organelles quickly extruded and phagocytosed without eliciting inflammatory response.

Apoptotic bodies(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.20

72

Clear vacuoles within parenchymal cells, displacing the nucleus to the cell periphery.

Fatty change (TOPNOTCHRobbins Basic Pathology, 8th ed. p.24

73

Focal, intracellular fat deposits creating alternating bands of yellowed myocardium with alternating bands of darker red-brown uninvolved heart or "tigered effect".

Fatty change of the heart(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.24

74

Rounded, eosinophilic accumulation of newly synthesized immunoglobulins in the rough ER of plasma cells.

Russel bodies(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.25

75

Eosinophilic cytoplasmic inclusion in liver cells composed of aggregated intermediate filaments which resist degradation. Seen in patients woth alcoholic liver disease.

Mallory body / "alcoholic hyalin"(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.25

76

Aggregated protein inclusions that contain microtubule-associated proteins and neurofilaments, reflecting disrupted neuronal cytoskeleton.

Neurofibrillary tangles in Alzheimer's disease(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.26

77

An insoluble brownish-yellow granular intracellular material that accumulates as a function of age and atrophy. Appears as perinuclear electron-dense granules on electron microscopy.

Lipofuschin(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.26

78

What substance accumulates in the cytoplasm of liver cells in steatosis?

Triglyceride (TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 62

79

Mechanism of triglyceride accumulation in malnutrition

Defective transport (TOPNOTCH)

80

A 70 y/o woman was brought to the clinic because of a 3 year history of progressive memory impairment, difficulty finding words, and irritability. What is the pathogenesis of this condition?

Abnormal folding of AB peptides causing aggregation within neurons and apoptosis (Case of Alzheimer Disease) (TOPNOTCH)

81

Pathogenesis: abnormal folding of PrPSC causing neuronal death (affected prion protein)

Creutzfeldt-Jacob disease (TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 58

82

Pathogenesis: absence of enzymatic activity in lungs causing destruction of elastic tissue

Alpha-1-antitrypsin deficiency (TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 58

83

Fundamental cause of necrotic cell death

Reduction in ATP levels(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 45

84

Other term for fatty change

Steatosis(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 62

85

Most common causes of significant fatty change in the liver

Alcohol abuse and non-alcoholic fatty liver disease(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 62

86

Alteration within the cells or in the extracellular space that gives a homogeneous, glassy, pink appearnce in H&E histologic section

Hyaline change(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 61

87

In this disease, glycogen can be seen in renal tubular epithelial cells, liver cells, B cells of islets of Langerhans, and heart muscle cells.

Diabetes mellitus(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 64

88

A condition when there is systemic overload of iron, hemosiderin may be deposited in many organs and tissues.

Hemosiderosis(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 65

89

An inherited disease characterized by extreme accumulation of iron, associated with liver, heart, and pancreatic damage, and resulting in liver fibrosis, heart failure, and diabetes mellitus.

Hemochromatosis. (TOPNOTCH)

90

A rare metabolic disease causing black pigment deposition in the skin, connective tissue, and cartilage.

Alkaptonuria(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 64

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