Hypercoaguable States Flashcards Preview

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Flashcards in Hypercoaguable States Deck (18)
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1
Q

Factor V Leiden- Eti

A

Common in caucasians. Hereitable disorder- leiden variant in factor V resulting in increased clotting. Inability of protein C to inactivate

2
Q

Factor V Leiden- Sx

A

Excessive clotting, superficial and deep DVTs, PEs less common. Exacerbated by estrogen, pregnancy.

3
Q

Antiphospholipid antibody syndrome- Eti

A

Autoab mediated thrombophilia. Assoc with SLE, scleroderma, sjogrens, RA

4
Q

Antiphospholipid antibody syndrome-Sx

A

Arterial or venous thrombotic event, multiple pregnancy loss

5
Q

Antiphospholipid antibody syndrome- DX

A

Immunoassasys for antiphospholipid Abs.

6
Q

Antiphospholipid antibody syndrome- Tx

A

Lifelong warfarin, INR monitoring

7
Q

Protein C deficiency- Eti

A

Heritable disorder causing loss of function of protein C- increased clotting

8
Q

Protein C deficiency- Sx

A

Purpura fulminans in newborns (coagulation in small vessels leading to necrosis), increased clot formation leading to thrombotic events

9
Q

Protein C deficiency- Dx

A

Immunologic assay

10
Q

Protein C deficiency– Tx

A

Warfarin

11
Q

Homocystinemia- Eti

A

Genetic disorder leading to abnormal methionine metabolism- elevated homocystine in blood.

12
Q

Protein S deficiency- Eti

A

Rare heterogenous genetic disorder. Low or abnormal function of protein S- unregulated coagulation. Can also be acquired due to low Vit K

13
Q

Protein S deficiency- Sx

A

Increased risk of DVT, PE, stroke, purport fulmains in adults

14
Q

Protein S deficiency- Tx

A

Warfarin

15
Q

Homocytinemia-Eti

A

Autosomal recessive deficiency of cytathionine Beta synthase. Extreme elevation of plasma and urinary homocysteine

16
Q

Homocytienemia-Sx

A

Mental retardation, marfan habitus, reduced life expectancy, increased risk of VTE

17
Q

Homocytienemia-Dx

A

Repeated thromboses with no other risk factors- plasma aa analysis of methionine and homocyteine.

18
Q

Homocytienemia-Tx

A

Pyridoxine & folate