Flashcards in Hypercoaguable States Deck (18)
Factor V Leiden- Eti
Common in caucasians. Hereitable disorder- leiden variant in factor V resulting in increased clotting. Inability of protein C to inactivate
Factor V Leiden- Sx
Excessive clotting, superficial and deep DVTs, PEs less common. Exacerbated by estrogen, pregnancy.
Antiphospholipid antibody syndrome- Eti
Autoab mediated thrombophilia. Assoc with SLE, scleroderma, sjogrens, RA
Antiphospholipid antibody syndrome-Sx
Arterial or venous thrombotic event, multiple pregnancy loss
Antiphospholipid antibody syndrome- DX
Immunoassasys for antiphospholipid Abs.
Antiphospholipid antibody syndrome- Tx
Lifelong warfarin, INR monitoring
Protein C deficiency- Eti
Heritable disorder causing loss of function of protein C- increased clotting
Protein C deficiency- Sx
Purpura fulminans in newborns (coagulation in small vessels leading to necrosis), increased clot formation leading to thrombotic events
Protein C deficiency- Dx
Protein C deficiency-- Tx
Genetic disorder leading to abnormal methionine metabolism- elevated homocystine in blood.
Protein S deficiency- Eti
Rare heterogenous genetic disorder. Low or abnormal function of protein S- unregulated coagulation. Can also be acquired due to low Vit K
Protein S deficiency- Sx
Increased risk of DVT, PE, stroke, purport fulmains in adults
Protein S deficiency- Tx
Autosomal recessive deficiency of cytathionine Beta synthase. Extreme elevation of plasma and urinary homocysteine
Mental retardation, marfan habitus, reduced life expectancy, increased risk of VTE
Repeated thromboses with no other risk factors- plasma aa analysis of methionine and homocyteine.