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Flashcards in Hypercoaguable States Deck (18)
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1

Factor V Leiden- Eti

Common in caucasians. Hereitable disorder- leiden variant in factor V resulting in increased clotting. Inability of protein C to inactivate

2

Factor V Leiden- Sx

Excessive clotting, superficial and deep DVTs, PEs less common. Exacerbated by estrogen, pregnancy.

3

Antiphospholipid antibody syndrome- Eti

Autoab mediated thrombophilia. Assoc with SLE, scleroderma, sjogrens, RA

4

Antiphospholipid antibody syndrome-Sx

Arterial or venous thrombotic event, multiple pregnancy loss

5

Antiphospholipid antibody syndrome- DX

Immunoassasys for antiphospholipid Abs.

6

Antiphospholipid antibody syndrome- Tx

Lifelong warfarin, INR monitoring

7

Protein C deficiency- Eti

Heritable disorder causing loss of function of protein C- increased clotting

8

Protein C deficiency- Sx

Purpura fulminans in newborns (coagulation in small vessels leading to necrosis), increased clot formation leading to thrombotic events

9

Protein C deficiency- Dx

Immunologic assay

10

Protein C deficiency-- Tx

Warfarin

11

Homocystinemia- Eti

Genetic disorder leading to abnormal methionine metabolism- elevated homocystine in blood.

12

Protein S deficiency- Eti

Rare heterogenous genetic disorder. Low or abnormal function of protein S- unregulated coagulation. Can also be acquired due to low Vit K

13

Protein S deficiency- Sx

Increased risk of DVT, PE, stroke, purport fulmains in adults

14

Protein S deficiency- Tx

Warfarin

15

Homocytinemia-Eti

Autosomal recessive deficiency of cytathionine Beta synthase. Extreme elevation of plasma and urinary homocysteine

16

Homocytienemia-Sx

Mental retardation, marfan habitus, reduced life expectancy, increased risk of VTE

17

Homocytienemia-Dx

Repeated thromboses with no other risk factors- plasma aa analysis of methionine and homocyteine.

18

Homocytienemia-Tx

Pyridoxine & folate