Hodgkin Lymphoma Flashcards Preview

Cancer > Hodgkin Lymphoma > Flashcards

Flashcards in Hodgkin Lymphoma Deck (14)
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1
Q

Lymphoid organs

A

Primary- bone barrow

Secondary- organs

2
Q

B cells differentiate into what where

A

Plasma cells in medulla

3
Q

Plasma cells produce

A

Antibodies

4
Q

B cells develop into

A

Plasma cells and produce antibodies

Some become centroblasts- which form germinal center

5
Q

Centrocyte turns to

A

Plasma cell

Or memory B cell

6
Q

What happens in the lymphoma/ how does it start

A

B cell has abnormal antibody gene rearrangement in germinal centre

Begins to divide uncontrollably

7
Q

Hodgkin lymphoma features

A

Spreads to nearby nodes (contigously)

Rarely extranodial

Has reed sternberg cells

8
Q

Non Hodgkin lymphoma features

A

Spreads non contigously

Extranodal sites

No reed- sternberg cells

9
Q

Cripples cels features

A

No antibodies produced
Surrounded by inflammatory cells
Activate fibroblasts and eosinophils

10
Q

Neoplasticism cells express

A

CD15 +CD30

11
Q

Symptoms

A

Fever
Night sweat
Fatigue

Painless cervical adenopathy

12
Q

Diagnosis

A

Ct to establish stage

Lymph node biopsy for diagnosis

13
Q

Treatment

A

Chemo/radiation

For modular lymphocyte predominant can use rituximab

14
Q

Prognosis

A

Better than non Hodgkin lymphoma