Hemoglobin, Hemoglobinopathies, and Thalassemia Flashcards Preview

Blood and Lymph > Hemoglobin, Hemoglobinopathies, and Thalassemia > Flashcards

Flashcards in Hemoglobin, Hemoglobinopathies, and Thalassemia Deck (29)
Loading flashcards...
1

____ has two alpha chains and two delta chains

HbA2

2

____ has two alpha chains and two epsilon chains

Hb Gower II

3

____ has two alpha chains and two gamma chains

HbF

4

____ has two zeta chains and two epsilon chains

Hb Gower

5

____ has two zeta chains and two gamma chains

Hb Portland

6

_____ induces production of fetal hemoglobin

hydroxyurea

7

______ consists of four beta chains

HbH

8

______ consists of four gamma chains

Hb Barts

9

______ is an important cause of aplastic crisis in children.

Parvovirus B19

10

2,3-BPG stabilizes hemoglobin in the ____ conformation

T

11

As 2,3-BPG increases, oxygen affinity _____ (____ shift)

decreases; right

12

As carbon dioxide concentration increases, oxygen affinity ____ (___ shift)

decreases; right

13

As pH increases, oxygen affinity _____ (___ shift)

increases; left

14

As temperature increases, oxygen affinity _____ (___ shift)

decreases; right

15

Extramedullary erythropoiesis and frontal bossing are associated with ______.

Thalassemia

16

Hydrops fetalis is most likely to occur in offspring of ______ descent.

Asian

17

In sickle cell anemia, bilirubin, LDH, and AST are _____.

increased

18

In sickle cell anemia, platelet count is _____.

increased

19

In sickle cell anemia, reticulocytes count is _____.

increased

20

In sickle celll anemia, RDW is _____.

increased

21

In thalassemia, bilirubin, LDH, and AST are _____.

increased

22

In thalassemia, MCV is ______.

decreased

23

In thalassemia, reticulocyte count is _____.

increased

24

Methemoglobinemia results in a ____ shift on the hemoglobin binding curve

left

25

Oxidation of Iron (II) to Iron (III) converts hemoglobin into ______.

methemoglobin

26

The high affinity conformation is the ___ conformation

R

27

The low affinity conformation is the ___ conformation

T

28

What condition is characterized by dark, chocolate covered blood?

Methemoglobinemia

29

What condition is characterized by headache, malaise, nausea, dizziness; can even have seizures, coma, or myocardial infarction or late neurologic deficits (cognition loss, personality change, movement disorders)?

Carbon Monoxide poisoning