Hemeonc MSK Flashcards Preview

FA notes > Hemeonc MSK > Flashcards

Flashcards in Hemeonc MSK Deck (110)
Loading flashcards...
1

Anisocytosis

varying sizes

2

Poikilocytosis

varying shapes

3

thrombocytopenia/platelet dysfunction results in

petechiae

4

Cell surface marker for Macrophages?

MC14

5

What causes eosinophilia?

DNAAACP
Drugs
Neoplasms
Atopy/allergy
Addisons
Acute interstitial neph
Collagen vascular dx
Parasites- helminths
- Churgg Strauss

6

funtion of a mast cell?

binds to the Fc portion of IgE to membrane
- cross linking of IgE causes degranulation releasing histamine, heparin and eosinophil chemotactic factors

7

only APC that can activate NK cells?

Dendritic cells- acts as a linke between innate and adaptive immune system

8

CD28

marker of T cells, necessary for t cell activation

9

what enzyme does warfarin inhibit?

epoxide reductase which usually activates vitamin K to make mature clotting factors

10

Role of kallikrein?

activates bradykinin and complement cascade (via activation of plasmin)

11

C1 esterase inhibitor?

inhibits kallikrein > brakykinin, so a deficiency causes a buildup of bradykinin, leading to angioedema

12

role of plasmin?

decreases the fibrin clot

13

What does the endothelial cell make in terms of thrombogenesis?

vWF
thromboplastin
tPA
PGI2

14

when do you see a acanthocyte?

abetalipoproteinemia

15

When do you see target cells?

HALT
HbC
Asplenia
Liver disease
Thalassemia

16

>3.4% HbA2

diagnostic confirmation fo B Thal minor

17

what are the genetics behind beta thal?

- point mutations in splice sites and promoter sequences decreasing B globin synthesis
(Alpha thal = gene deletions)

18

crew cut on skull xray, chipmunk facies

beta thal major- homozygotes, stop codon, increased HbF

19

what are the aggregates seen in basophilic stipling?

rRNA aggregates

20

where in the bone does lead target?

epiphysis of distal femur and proximal tibia

21

Pathogenesis of sideroblastic anemia

X linked defect in d-ALA synthase gene
- also seen in alcohol, lead and INH deficiency

22

tx of sideroblastic anemia?

pyridoxine- B6 is a cofactor for ALA synthase

23

findings of intravascular hemolysis

decreased haptoglobin
increased LDH
hemoglobinuria

24

Extravascular hemolysis findings

increased LDH
increased UCB > jaundice

25

What viruses can cause Aplastic anemia?

Parvo B19
EBV
HCV
HIV

26

how does pyruvate kinase deficiency cause anemia?

defective pyruvate kinase causes decreased ATP > rigid RBCs
- hemolytic anemia in newborn

27

whats the defect behidn HbC?

glutamic acid to lysine mutation in B globin gene

28

treatment of PNH?

eculizumab

29

genetics of HbS?

substitution of glutamic acid with val in Beta chain

30

What drug could cause Warm agglutinin autoimmune hemolytic anemia?

alpha-methyldopa